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A bistable switch in dynamic thiodepsipeptide folding and template-directed ligation.

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Area of Science:

  • Systems Chemistry
  • Synthetic Biology
  • Chemical Kinetics

Background:

  • Living cells utilize bistable reaction networks for long-term memory storage and switching.
  • Developing synthetic, non-enzymatic equivalents remains a significant challenge in systems chemistry.

Purpose of the Study:

  • To design and characterize a synthetic, non-enzymatic dynamic network exhibiting bistability.
  • To investigate the relationship between network topology and bistability through experiments and theory.

Main Methods:

  • Construction of a dynamic reaction network based on thiodepsipeptide concentrations.
  • Experimental control and theoretical analysis to study network behavior and bistability.
  • Analysis of reaction network topology and its influence on invoking bistable states.

Main Results:

  • A synthetic dynamic network was developed that transitions to one of two distinct steady states based on initial concentrations.
  • The bistable system demonstrated switchability upon application of appropriate stimuli.
  • Control experiments and theoretical analysis elucidated the link between network topology and bistability.

Conclusions:

  • Demonstrated a synthetic, non-enzymatic bistable reaction network, mimicking cellular memory functions.
  • The findings suggest potential roles for synthetic bistable networks in early chemical evolution.
  • Highlights potential applications in areas such as chemical memory devices.