Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Drug Toxicity: Allergic Reactions01:30

Drug Toxicity: Allergic Reactions

147
Drug-related allergies are immune-mediated responses triggered by the administration of pharmacological agents. These hypersensitivity reactions are classified based on the immune mechanisms involved. The four primary types—Type I, II, III, and IV—are mediated by different immunological pathways and exhibit distinct clinical manifestations.Type I Hypersensitivity/ IgE-Mediated Reactions: Immunoglobulin E (IgE) immediately mediates Type I hypersensitivity reactions. Upon initial...
147
Skin Diseases and Disorders01:23

Skin Diseases and Disorders

6.2K
Skin is the first line of defense and encounters a variety of microbes. Some pathogenic strains are often the cause of a broad range of infections of the skin and other body systems. These conditions can affect people of all ages and may have different causes, including genetic factors, infections, autoimmune reactions, environmental factors, and lifestyle choices.
Gram-positive Staphylococcus spp. and Streptococcus spp. are responsible for many of the most common skin infections. However, many...
6.2K
Sensory Functions of the Skin01:16

Sensory Functions of the Skin

9.4K
The skin is the largest organ of the human body and plays a crucial role in our sensory perception. It contains a vast network of sensory receptors that contribute to the skin's protective function by perceiving physical, biological, and environmental cues and generating relevant responses.
There are two main categories of receptors on the skin: capsulated and non-capsulated. The non-capsulated ones are mainly the pain receptors. The capsulated ones can be further categorized based on the...
9.4K
Hypersensitivities01:30

Hypersensitivities

8.4K
Hypersensitivity, also known as a hypersensitivity reaction or allergic reaction, is a condition where the body's immune system reacts abnormally to a foreign substance. Such substances, that cause hypersensitivity are referred to as an allergen, could be something typically harmless to most people, like pollen or certain foods.
Types of Hypersensitivities
Hypersensitivity reactions are categorized into four types: Type 1, Type 2, Type 3, and Type 4. Each type has a distinct mechanism...
8.4K
Staphylococcal Skin Infections01:29

Staphylococcal Skin Infections

72
Staphylococcus aureus is a Gram-positive coccus that resides harmlessly on the skin and mucous membranes of healthy individuals. When the skin barrier is breached, it can shift from a commensal to an opportunistic pathogen. This transition is facilitated by surface adhesins, such as clumping factor B and S. aureus surface protein G (SasG), which bind to structural proteins, including loricrin and cytokeratin, in the damaged epidermis. Protein A, another key factor, binds the Fc region of...
72
Asthma: Pathogenesis and Management01:20

Asthma: Pathogenesis and Management

1.7K
Asthma is a chronic pulmonary condition involving inflammation of the airways, hyper-reactivity, and reversible obstruction of the airways. This condition can significantly impact a person's quality of life, making breathing difficult and leading to distressing symptoms.
Asthma is classified as allergic and non-allergic. Allergens such as dust mites, pollen, and pet dander trigger allergic asthma, while factors like cold air, intense emotions, or exercise can induce non-allergic asthma.
1.7K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Development of an ex vivo skin model for quantitative recovery and preservation of donor-specific human microbiota.

BMC microbiology·2026
Same author

Chronic pruritus treated with alendronate in bilateral striopallidodentate calcinosis associated with an SLC20A2 gene mutation.

Journal der Deutschen Dermatologischen Gesellschaft = Journal of the German Society of Dermatology : JDDG·2026
Same author

Response to Pham et al., "Sensory symptoms of scalp psoriasis are not sensitive scalp syndrome".

JAAD international·2026
Same author

Retrospective Assessment of Social Rejection Related to Atopic Dermatitis During Childhood and Adolescence: The Scars of Life-Eczema Study.

International journal of dermatology·2026
Same author

<sup>18</sup>F-FDG PET radiomic analysis to predict outcomes in metastatic melanoma treated with immune checkpoint inhibitors.

Frontiers in immunology·2026
Same author

Real-World Burden of Generalized Pustular Psoriasis in a French Observational Study: Prevalence, Incidence, Healthcare Resource Utilization, Comorbidities, Treatment Use, and Mortality.

Dermatology and therapy·2026
Same journal

A Facial Lesion with Cord-like Induration and Ring-like Appearance on MRI: A Quiz.

Acta dermato-venereologica·2026
Same journal

Real-world Outcomes of Adalimumab in Hidradenitis Suppurativa: A 10-year Retrospective Longitudinal Study.

Acta dermato-venereologica·2026
Same journal

An 8-year-old Girl with Multiple Whitish Dots on the Hair Shaft: A Quiz.

Acta dermato-venereologica·2026
Same journal

A Congenital Subcutaneous Tumour of the Scalp in a Child: A Quiz.

Acta dermato-venereologica·2026
Same journal

Commentary on: "The Effects of Sun Exposure and Pigmentation Phenotype on Prognosis in Metastatic Melanoma".

Acta dermato-venereologica·2026
Same journal

Treatment Response to JAK Inhibitors in Long-standing Alopecia Areata (≥8 Years): A Real-world Observational Study.

Acta dermato-venereologica·2026
See all related articles

Related Experiment Video

Updated: Apr 4, 2026

Granulocyte-dependent Autoantibody-induced Skin Blistering
12:23

Granulocyte-dependent Autoantibody-induced Skin Blistering

Published on: October 12, 2012

11.0K

Pathophysiological Study of Sensitive Skin.

Virginie Buhé1, Katell Vié, Christelle Guéré

  • 1Laboratory of Neurosciences of Brest (EA4685), University of Western Brittany, Avenue Camille Desmoulins, 29238 Brest Cedex, France.

Acta Dermato-Venereologica
|September 5, 2015
PubMed
Summary
This summary is machine-generated.

Sensitive skin may result from reduced nerve fiber density, particularly peptidergic C-fibers. This finding suggests a link between skin sensitivity and small fiber neuropathy.

More Related Videos

Contact Hypersensitivity as a Murine Model of Allergic Contact Dermatitis
08:25

Contact Hypersensitivity as a Murine Model of Allergic Contact Dermatitis

Published on: September 26, 2022

3.7K
Cutaneous Surgical Denervation: A Method for Testing the Requirement for Nerves in Mouse Models of Skin Disease
08:01

Cutaneous Surgical Denervation: A Method for Testing the Requirement for Nerves in Mouse Models of Skin Disease

Published on: June 26, 2016

10.7K

Related Experiment Videos

Last Updated: Apr 4, 2026

Granulocyte-dependent Autoantibody-induced Skin Blistering
12:23

Granulocyte-dependent Autoantibody-induced Skin Blistering

Published on: October 12, 2012

11.0K
Contact Hypersensitivity as a Murine Model of Allergic Contact Dermatitis
08:25

Contact Hypersensitivity as a Murine Model of Allergic Contact Dermatitis

Published on: September 26, 2022

3.7K
Cutaneous Surgical Denervation: A Method for Testing the Requirement for Nerves in Mouse Models of Skin Disease
08:01

Cutaneous Surgical Denervation: A Method for Testing the Requirement for Nerves in Mouse Models of Skin Disease

Published on: June 26, 2016

10.7K

Area of Science:

  • Dermatology
  • Neuroscience
  • Skin Biology

Background:

  • Sensitive skin presents as a clinical syndrome with various unpleasant sensations.
  • The underlying pathophysiology of sensitive skin remains largely unknown.
  • Symptoms suggest potential inflammation and peripheral nerve involvement.

Purpose of the Study:

  • To investigate the relationship between skin innervation and sensitive skin.
  • To compare intraepidermal nerve fiber density in sensitive versus non-sensitive skin.

Main Methods:

  • Systematic analysis of cutaneous biopsies from 50 healthy women.
  • Comparison of intraepidermal nerve fiber density between sensitive and non-sensitive skin groups.
  • Focus on peptidergic C-fibers involved in sensory perception.

Main Results:

  • Lower intraepidermal nerve fiber density was observed in the sensitive skin group.
  • A notable reduction in peptidergic C-fibers was found in individuals with sensitive skin.
  • Degeneration of these nerve fibers may contribute to symptoms like allodynia.

Conclusions:

  • The pathophysiology of sensitive skin may resemble neuropathic pruritus associated with small fiber neuropathy.
  • Environmental factors could potentially influence skin innervation.
  • Reduced nerve fiber density is a key finding in sensitive skin.