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Updated: Apr 4, 2026

Frailty Assessment in an Aging Mouse Model
Published on: September 23, 2025
Feasibility and construct validity of a Frailty index for patients with chronic kidney disease
Ruth E Hubbard1, Nancye M Peel1, Morgan Smith2,3
1Centre for Research in Geriatric Medicine, The University of Queensland, Brisbane, Queensland, Australia.
Aim:
To determine whether the frailty status of patients with chronic kidney disease (CKD) can be measured using a Frailty index (FI).
Methods:
One hundred and eleven attending a nephrology clinic were approached to complete a one-page questionnaire evaluating cognitive, psychological and functional status. Data were coded as deficits, summed and divided by the total number of deficits considered, to derive an FI-CKD.
Results:
One hundred and ten (mean age 65.2 years) agreed to participate and assessments took approximately 10 minutes to complete. Mean FI-CKD was 0.25 (SD 0.12). The FI-CKD increased with age at 3% per year, correlated with a modified Fried phenotype (P < 0.001) and increased significantly across CKD stages (P = 0.04).
Conclusions:
The FI-CKD is feasible in the outpatient setting and has good construct validity. The greater granularity of a continuous measure has the potential to inform decision-making regarding appropriate interventions for patients at the 'frail' end of the health spectrum.
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