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Updated: Apr 4, 2026
Digital PCR for Quantifying Circulating MicroRNAs in Acute Myocardial Infarction and Cardiovascular Disease
Published on: July 3, 2018
Circulating MicroRNA-146a and MicroRNA-21 Predict Left Ventricular Remodeling after ST-Elevation Myocardial
Objectives:
MicroRNA (miR)-146a and miR-21 have been reported to participate in inflammatory reactions and fibrosis.Excessive inflammation and cardiac fibrosis may play important roles in the development of left ventricular remodeling(LVR). This study assessed whether miR-146a, miR-21 and other biomarkers could predict LVR after myocardial infarction(MI).
Methods:
Circulating miR-146a, miR-21 and other biomarker levels were measured in 198 patients with acute MI 5 days after primary percutaneous coronary intervention(PCI). All patients were assessed by transthoracic echocardiography on day 5 and 1 year after primary PCI.
Results:
Concentrations of circulating miR-146a, miR-21, C-reactive protein, creatine kinase MB type and troponin I, as well as estimated glomerular filtration rate (eGFR) and left ventricular ejection fraction (LVEF), were significantly higher in patients with than in those without LVR (p < 0.05). Multivariate logistic regression analysis showed that circulating miR-146a (odds ratio, OR = 2.127, p < 0.0001), miR-21 (OR = 1.119,p < 0.0001), eGFR (OR = 0.939, p = 0.0137) and LVEF (OR =0.802, p = 0.0048) were independent predictors of LVR development. The area under the curve for the combination of miR-146a and miR-21 was significantly higher than for either alone.
Conclusion:
Circulating miR-146a and miR-21 may be novel biomarkers predictive of LVR after acute MI. Their combination may better predict LVR than either alone.
Insights
Circulating microRNA-146a and microRNA-21 show promise as novel biomarkers for predicting left ventricular remodeling after myocardial infarction. Combining these microRNAs offers improved predictive accuracy for LVR development.
Area of Science:
- Cardiovascular Medicine
- Biomarker Discovery
- Molecular Cardiology
Background:
- Left ventricular remodeling (LVR) is a significant complication after myocardial infarction (MI), driven by inflammation and fibrosis.
- MicroRNAs (miRs), specifically miR-146a and miR-21, are implicated in inflammatory processes and fibrosis.
- Identifying reliable predictors of LVR is crucial for patient management post-MI.
Purpose of the Study:
- To investigate the potential of circulating miR-146a and miR-21 as predictive biomarkers for LVR following acute MI.
- To assess other biomarkers in conjunction with miRs for their ability to predict LVR.
- To evaluate the combined predictive power of miR-146a and miR-21 for LVR development.
Main Methods:
- Measurement of circulating miR-146a, miR-21, and other biomarkers in 198 acute MI patients 5 days post-primary percutaneous coronary intervention (PCI).
- Assessment of LVR using transthoracic echocardiography at day 5 and 1 year after primary PCI.
- Multivariate logistic regression analysis to identify independent predictors of LVR.
Main Results:
- Patients who developed LVR had significantly higher levels of circulating miR-146a, miR-21, C-reactive protein, creatine kinase MB type, troponin I, and lower estimated glomerular filtration rate (eGFR) and left ventricular ejection fraction (LVEF).
- Circulating miR-146a (OR=2.127), miR-21 (OR=1.119), eGFR (OR=0.939), and LVEF (OR=0.802) were identified as independent predictors of LVR.
- The combination of miR-146a and miR-21 demonstrated a significantly higher area under the curve for predicting LVR compared to either biomarker alone.
Conclusions:
- Circulating miR-146a and miR-21 emerge as potential novel biomarkers for predicting LVR after acute MI.
- The combined assessment of miR-146a and miR-21 may offer superior predictive value for LVR development compared to individual measurements.
- These findings highlight the role of specific microRNAs in the pathophysiology of post-MI cardiac remodeling.
