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Reproducibility Between Brain Uptake Ratio Using Anatomic Standardization and Patlak-Plot Methods.

Takayuki Shibutani1, Masahisa Onoguchi2, Atsushi Noguchi3

  • 1Department of Quantum Medical Technology, Graduate School of Medical Sciences, Kanazawa University, Ishikawa, Japan.

Journal of Nuclear Medicine Technology
|September 5, 2015
PubMed
Summary

The new brain uptake ratio using anatomic standardization (BUR-AS) method significantly improves the reproducibility of cerebral blood flow measurements. This method offers greater reliability compared to conventional-BUR (BUR-C) and Patlak-plot techniques.

Keywords:
Patlak plot methodbrain perfusion SPECTbrain uptake ratiocerebral blood flow (CBF)reproducibility

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Area of Science:

  • Neuroimaging
  • Quantitative analysis
  • Medical physics

Background:

  • Conventional methods for determining brain uptake ratio (BUR) and Patlak-plot analysis exhibit limitations in reproducibility.
  • Improving the reliability of cerebral blood flow (CBF) measurements is crucial for accurate clinical assessment.

Purpose of the Study:

  • To introduce and evaluate a novel method for determining brain uptake ratio using anatomic standardization (BUR-AS).
  • To compare the inter- and intraoperator reproducibility of BUR-AS with conventional-BUR (BUR-C) and Patlak-plot methods for CBF measurement.

Main Methods:

  • Retrospective analysis of brain perfusion SPECT images from 30 patients.
  • Application of an automatic quantitative analysis tool for cerebral blood flow using ECD.
  • Calculation of mean cerebral blood flow using the BUR-AS method, involving anatomic standardization and region-of-interest selection on basal ganglia slices.
  • Evaluation of reproducibility using coefficient of variation and Bland-Altman plotting.

Main Results:

  • The BUR-AS method demonstrated the lowest coefficient of variation for both inter- and intraoperator reproducibility.
  • BUR-AS exhibited the smallest error range on Bland-Altman plots compared to other methods.
  • Mean CBF determined by BUR-AS showed the highest reproducibility.

Conclusions:

  • The BUR-AS method significantly enhances inter- and intraoperator reproducibility in cerebral blood flow measurements.
  • BUR-AS offers a more reliable alternative to the Patlak-plot and conventional-BUR (BUR-C) methods for quantitative CBF analysis.