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[The relation between carcinogenesis and mutagenesis: a re-evaluation].

H Bartsch, C Malaveille

Bulletin De L'Academie Nationale De Medecine

|November 1, 1989

Summary

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Genotoxic carcinogens significantly contribute to human cancer burden more than non-genotoxic ones. Short-term genotoxicity tests are crucial for identifying human cancer hazards and guiding primary cancer prevention strategies.

Area of Science:

Toxicology
Carcinogenesis
Genetics

Context:

Analysis of agents from IARC Monographs Supplements 6 and 7.
Evaluation of carcinogenic effects in humans and animals.
Assessment of activity in short-term genotoxicity tests.

Purpose:

Determine if genotoxic and non-genotoxic carcinogens contribute similarly to human cancer burden.
Identify short-term tests most relevant for predicting human hazards.
Analyze genotoxicity prevalence across different carcinogen classifications.

Summary:

High prevalence (80-90%) of genotoxic carcinogens found in established (group 1), probable (group 2A), and possible (group 2B) human carcinogens.
Genotoxic carcinogens were often associated with multi-species or multi-tissue carcinogenicity.

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Carcinogenic potency in rodents did not clearly differentiate human carcinogens from others.

Impact:

Genotoxic carcinogens appear to contribute more to the human cancer burden than non-genotoxic ones.
Continued use of in vitro/in vivo short-term genotoxicity tests is justified for hazard identification.
Genotoxicity assays are vital for identifying potential human hazards and informing cancer prevention efforts.