Related Experiment Video
Updated: Apr 4, 2026

Microbiota Analysis Using Two-step PCR and Next-generation 16S rRNA Gene Sequencing
Published on: October 15, 2019
The gut microbiota and host health: a new clinical frontier
Julian R Marchesi1, David H Adams2, Francesca Fava3
1School of Biosciences, Museum Avenue, Cardiff University, Cardiff, UK Centre for Digestive and Gut Health, Imperial College London, London, UK.
Abstract:
Over the last 10-15 years, our understanding of the composition and functions of the human gut microbiota has increased exponentially. To a large extent, this has been due to new 'omic' technologies that have facilitated large-scale analysis of the genetic and metabolic profile of this microbial community, revealing it to be comparable in influence to a new organ in the body and offering the possibility of a new route for therapeutic intervention. Moreover, it might be more accurate to think of it like an immune system: a collection of cells that work in unison with the host and that can promote health but sometimes initiate disease. This review gives an update on the current knowledge in the area of gut disorders, in particular metabolic syndrome and obesity-related disease, liver disease, IBD and colorectal cancer. The potential of manipulating the gut microbiota in these disorders is assessed, with an examination of the latest and most relevant evidence relating to antibiotics, probiotics, prebiotics, polyphenols and faecal microbiota transplantation.
Related Concept Videos
Introduction to the Human Microbiota
Functions of the Gut Microbiota
The Oral Microbiota
Microbiota of the Large Intestine
Microbiota of the Stomach and Small Intestine
Development of Human Microbiota

