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Related Experiment Video

Updated: Apr 4, 2026

A Microfluidic Chip for ICPMS Sample Introduction
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High-throughput sorting of drops in microfluidic chips using electric capacitance.

Arjen M Pit1, Riëlle de Ruiter1, Anand Kumar1

  • 1Physics of Complex Fluids Group, MESA+ Institute, University of Twente , P.O. Box 217, 7500 AE Enschede, The Netherlands.

Biomicrofluidics
|September 5, 2015
PubMed
Summary

This study presents an electrostatic microfluidic chip for sorting biological drops in oil. The device uses electrowetting and two-phase flow to achieve high-throughput, precise sorting of conductive biological samples.

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Area of Science:

  • Microfluidics
  • Electrokinetics
  • Biotechnology

Background:

  • Microfluidic devices are crucial for biological sample manipulation.
  • Sorting biological samples with high throughput remains a challenge.
  • Electrowetting offers precise control but often lacks high throughput.

Purpose of the Study:

  • To analyze a novel microfluidic sorter combining electrowetting and two-phase flow.
  • To demonstrate efficient sorting of aqueous drops with biological content in oil.
  • To evaluate the device's performance for conductive biological media.

Main Methods:

  • Utilized a microfluidic chip with three co-planar electrodes beneath the fluidic channel.
  • Employed electrowetting principles to create an electrical guide for drop deflection.
  • Leveraged conductivity contrast between aqueous drops and the continuous oil phase.

Main Results:

  • Achieved sorting speeds up to 1200 drops per second.
  • Demonstrated successful sorting of conductive biological drops (e.g., phosphate-buffered saline).
  • Validated a capacitive model for predicting electrostatic forces and drop deflection.

Conclusions:

  • The electrostatic sorter effectively sorts biological drops in oil using a hybrid microfluidic approach.
  • The method protects biological contents from electrical damage and Joule heating.
  • High sorting rates are achievable, overcoming limitations of traditional electrowetting methods.