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Primary malignant mixed tumor of bone: a case report
Zhansan Su1, Zhi Li1, Baoan Liu2
1Department of Pathology, Xiangya Third Hospital, Central South University Changsha 410013, Hunan Province, China.
International Journal of Clinical and Experimental Pathology
|September 5, 2015
Summary
A rare primary malignant mixed tumor of the femur was successfully treated with curettage, bone grafting, and hip replacement. Long-term follow-up confirmed no recurrence, indicating a favorable prognosis for this rare bone tumor.
Area of Science:
- Orthopedic Oncology
- Skeletal Tumors
- Tumor Pathology
Background:
- Reports an extremely rare case of primary malignant mixed tumor in the left proximal femur of a 47-year-old female.
- Highlights the rarity of primary mixed tumors in long bones.
Observation:
- Initial presentation of left hip pain and a translucent expansive lesion in the greater trochanter.
- Diagnosis of malignant mixed tumor, initially suspected as metastatic.
- Recurrence five months post-initial surgery, necessitating obturator neurotomy and total hip replacement.
Findings:
- Histopathological analysis revealed a mixed tumor with myoepithelial and epithelial components, positive for S-100, p63, CK-pan, CK-LMW, and vimentin.
- Tumor exhibited cellular atypia, high mitosis index, grade I chondrosarcoma features, necrosis, and infiltration, indicating low-grade malignancy.
- Immunohistochemistry and histopathology confirmed a primary malignant mixed tumor of the femur.
Implications:
- Successful management of a rare malignant mixed tumor through surgical intervention and long-term follow-up.
- Demonstrates the possibility of favorable outcomes even with aggressive initial presentation and recurrence.
- Emphasizes the importance of thorough histopathological evaluation and long-term surveillance for rare bone tumors.
