Related Experiment Video
Updated: Apr 4, 2026

A Silicosis Mouse Model Established by Repeated Inhalation of Crystalline Silica Dust
Published on: January 6, 2023
Pleuroparenchymal fibroelastosis associated with aluminosilicate dust: a case report
Ziling Huang1, Shuai Li1, Yi Zhu2
1Department of Pathology, Shanghai Tongji Hospital, Tongji University School of Medicine Shanghai, China.
Idiopathic pleuroparenchymal fibroelastosis (IPPFE), a rare lung fibrosis, may be caused by inhaling dust. This finding suggests a new potential cause for this progressive and poorly understood condition.
Area of Science:
- Pulmonology
- Environmental Medicine
- Pathology
Background:
- Idiopathic pleuroparenchymal fibroelastosis (IPPFE) is a rare interstitial lung disease.
- It is characterized by fibrosis predominantly in the upper lobes.
- The etiology of IPPFE remains largely unknown, with a progressive clinical course and poor prognosis.
Related Concept Videos
Chronic Obstructive Pulmonary Disease-II: Pathophysiology
Chronic Inflammation
Chronic Obstructive Pulmonary Disease-I: Introduction
COPD: Pathogenesis and Clinical Features
The primary cause for the onset of COPD is cigarette smoking and exposure to air pollution. These hazardous factors initiate a chain reaction within the lungs, resulting in chronic inflammation, damage to the airways, and a...
Chronic Obstructive Pulmonary Disease
Smoking is a primary risk factor for COPD, with over 80% of patients having a history of it. Patients typically experience progressive dyspnea or labored breathing, frequent coughing, and recurrent pulmonary infections. Many eventually succumb to respiratory failure, characterized by...
Chronic Obstructive Pulmonary Disease-III: Symptoms and Complications.
Symptoms of COPD can be classified as primary or systemic. Primary symptoms relate to reduced airflow, while systemic or extrapulmonary symptoms relate to COPD's broader impact on the body.
Primary Symptoms of COPD:

