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Related Experiment Videos

Leukocyte function after aortic valve replacement.

B Kvarstein, J Dale

    American Heart Journal
    |November 1, 1978
    PubMed
    Summary
    This summary is machine-generated.

    Leukocyte function, measured by phagocytosis, remains largely unaffected in patients with Starr-Edwards aortic ball valves. This study found no significant reduction in phagocytotic capacity after valve implantation, suggesting preserved immune cell function.

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    Area of Science:

    • Immunology
    • Biomedical Engineering
    • Cardiovascular Surgery

    Background:

    • Prosthetic heart valves are crucial for patients with valvular disease.
    • Assessing the impact of these devices on immune function is important for long-term patient health.
    • Leukocyte phagocytosis is a key indicator of cellular immune capacity.

    Purpose of the Study:

    • To evaluate leukocyte phagocytotic capacity in patients with Starr-Edwards aortic ball valves.
    • To determine if prosthetic heart valve implantation significantly alters immune cell function.

    Main Methods:

    • Oxygen consumption during phagocytosis of polystyrene latex particles was measured.
    • Leukocyte counts and cell type distribution were analyzed.
    • Data from 38 patients with prosthetic valves were compared to 50 healthy controls.

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    Main Results:

    • Mean oxygen consumption in patients was 3.95 nanoatoms/min/10^6 leukocytes, compared to 4.15 in controls.
    • The difference in oxygen consumption was not statistically significant.
    • Leukocyte counts and cell type distribution were similar, with a slight increase in younger cells in patients.

    Conclusions:

    • Aortic ball valve implantation does not significantly impair the phagocytotic capacity of leukocytes.
    • Immune cell function, specifically phagocytosis, appears to be preserved in patients with Starr-Edwards aortic ball valves.