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Updated: Apr 4, 2026

Methylated DNA Immunoprecipitation
Published on: January 2, 2009
Environmental Epigenetics: Crossroad between Public Health, Lifestyle, and Cancer Prevention
Massimo Romani1, Maria Pia Pistillo1, Barbara Banelli1
1Laboratory of Tumor Epigenetics, IRCCS AOU San Martino-IST, Largo Rosanna Benzi 10, 16132 Genova, Italy.
Abstract:
Epigenetics provides the key to transform the genetic information into phenotype and because of its reversibility it is considered an ideal target for therapeutic interventions. This paper reviews the basic mechanisms of epigenetic control: DNA methylation, histone modifications, chromatin remodeling, and ncRNA expression and their role in disease development. We describe also the influence of the environment, lifestyle, nutritional habits, and the psychological influence on epigenetic marks and how these factors are related to cancer and other diseases development. Finally we discuss the potential use of natural epigenetic modifiers in the chemoprevention of cancer to link together public health, environment, and lifestyle.
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