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Aptamer-based surface-enhanced Raman scattering-microfluidic sensor for sensitive and selective polychlorinated

Cuicui Fu1, Yi Wang1, Gang Chen1,2

  • 1State Key Laboratory of Supramolecular Structure and Materials, Institute of Theoretical Chemistry, Jilin University , 2699 Qianjin Avenue, Changchun 130012, P. R. China.

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|September 5, 2015
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Summary

This study presents a novel aptamer-modified microfluidic sensor for detecting 3,3

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Area of Science:

  • Environmental Science
  • Analytical Chemistry
  • Materials Science

Background:

  • Polychlorinated biphenyls (PCBs) are persistent organic pollutants with significant environmental and health concerns.
  • Sensitive and selective detection methods are crucial for monitoring PCB contamination.
  • Surface-enhanced Raman scattering (SERS) offers high sensitivity for molecular detection.

Purpose of the Study:

  • To develop an aptamer-based microfluidic sensor for the sensitive and selective detection of 3,3',4,4'-tetrachlorobiphenyl (PCB77).
  • To integrate SERS technology with aptamer recognition in a microfluidic platform for enhanced pollutant detection.

Main Methods:

  • Fabrication of a microfluidic chip using patterned polydimethylsiloxane (PDMS) and an ordered silver (Ag) nanocrown array.
  • Immobilization of PCB77-specific aptamers onto the Ag nanocrown array via S-Ag bonds for target capture.
  • Utilizing SERS for sensitive detection of captured PCB77 within the microfluidic device.

Main Results:

  • The aptamer-modified SERS microfluidic chip achieved rapid detection of PCB77.
  • A lowest detectable concentration of 1.0 × 10⁻⁸ M for PCB77 was successfully demonstrated.
  • The sensor exhibited enhanced sensitivity and selectivity for PCB77 detection.

Conclusions:

  • The developed aptamer-modified SERS microfluidic sensor is effective for selective detection of organic pollutants like PCB77.
  • This platform shows potential for environmental monitoring applications.
  • Integration of aptamers and SERS in microfluidics enhances analytical capabilities for pollutant analysis.