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Clinical Significance of Antibiotic Resistance

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In addition to multiple alleles at the same locus influencing traits, numerous genes or alleles at different locations may interact and influence phenotypes in a phenomenon called epistasis. For example, rabbit fur can be black or brown depending on whether the animal is homozygous dominant or heterozygous at a TYRP1 locus. However, if the rabbit is also homozygous recessive at a locus on the tyrosinase gene (TYR), it will have an unshaded coat that appears white, regardless of its TYRP1...
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Development of an in vitro model system for studying the interaction of Equus caballus IgE with its high-affinity receptor FcεRI
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Genetic Susceptibility to Rhodococcus equi.

C M McQueen1, S V Dindot2, M J Foster3

  • 1Department of Large Animal Clinical Sciences, Texas A&M University, College Station, TX.

Journal of Veterinary Internal Medicine
|September 5, 2015
PubMed
Summary
This summary is machine-generated.

Understanding foal genetics is key to combating Rhodococcus equi pneumonia. This review explores genetic approaches to identify susceptible horses and improve treatment strategies for this foal disease.

Keywords:
Copy number variantsGenome-wide association studyHorsesPneumoniaRhodococcus equi

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Area of Science:

  • Equine medicine
  • Genetics
  • Infectious diseases

Background:

  • Rhodococcus equi pneumonia significantly impacts foal health and survival.
  • Current preventative and treatment strategies for R. equi have limited success.
  • Understanding the genetic basis of disease susceptibility is crucial for developing effective interventions.

Purpose of the Study:

  • To review past research on the genetic underpinnings of R. equi susceptibility and tolerance in foals.
  • To highlight available genetic technologies for equine research.
  • To explain the application of these technologies in studying R. equi.

Main Methods:

  • Review of existing literature on equine genetics and R. equi.
  • Description of genetic technologies including candidate gene approaches.
  • Explanation of genome-wide association studies (GWAS) using single nucleotide polymorphisms (SNPs) and copy number variants (CNVs).
  • Overview of next-generation sequencing (NGS) for DNA and RNA analysis.

Main Results:

  • Past efforts to understand the genetic basis of R. equi susceptibility have yielded limited success.
  • Various genetic technologies are available for equine research.
  • These technologies offer powerful tools for investigating host-pathogen interactions in R. equi infections.

Conclusions:

  • Genetic factors play a role in foal susceptibility and tolerance to R. equi.
  • Advanced genetic technologies like GWAS and NGS are essential for future research.
  • Further investigation into equine genetics can lead to improved disease management and prevention strategies for R. equi pneumonia.