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Ascorbic and dehydroascorbic acids status in rats fed diets varying in vitamin E levels.

W A Behrens1, R Madère

  • 1Bureau of Nutritional Sciences, Food Directorate, Health Protection Branch, Ottawa, Ontario, Canada.

International Journal for Vitamin and Nutrition Research. Internationale Zeitschrift Fur Vitamin- Und Ernahrungsforschung. Journal International De Vitaminologie Et De Nutrition
|January 1, 1989
PubMed
Summary

Dietary vitamin E intake minimally impacts vitamin C levels in rat tissues and plasma. In vivo interactions between vitamin E and vitamin C are limited, likely due to biological membrane complexity.

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Area of Science:

  • Biochemistry
  • Nutrition Science
  • Toxicology

Background:

  • Vitamin E and vitamin C are crucial antioxidants with known in vitro interactions.
  • Understanding their in vivo relationship is vital for nutritional and health research.

Purpose of the Study:

  • To investigate the in vivo correlation between dietary vitamin E levels and vitamin C status in rat plasma and tissues.
  • To determine if observed in vitro interactions between these vitamins occur within a biological system.

Main Methods:

  • Rats were fed diets with varying vitamin E content (5, 50, or 250 IU) for 2-3 months.
  • Plasma and tissue concentrations of vitamin E, ascorbic acid, and dehydroascorbic acid were quantified.

Main Results:

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  • Total vitamin C showed minor increases in liver, kidney, spleen, and plasma with high vitamin E diets (LE vs. HE).
  • The ascorbate/dehydroascorbate ratio did not significantly increase, indicating limited impact on vitamin C redox state.
  • No direct correlation was found between vitamin E and vitamin C levels within tissues.

    • Conclusions:

    • Dietary vitamin E has a limited effect on vitamin C levels in vivo.
    • The complex biological environment of cell membranes may prevent the direct in vivo interactions observed in vitro between vitamin E and vitamin C.