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High-sensitivity C-reactive protein and mean platelet volume as predictive values after percutaneous coronary
Ae Ran Moon1, Dong-Hyun Choi, Su-Young Jahng
1aDivision of Natural Medical Sciences, College of Health Science, Chosun University bDepartment of Internal Medicine cDepartment of Thoracic and Cardiovascular Surgery dDepartment of Anesthesiology and pain Medicine, Chosun University School of Medicine, Gwangju eDepartment of Thoracic and Cardiovascular Surgery, St. Carollo General Hospital, Jeollanam-do fDepartment of Biochemistry and Molecular Biology, Chosun University School of Medicine, Gwangju, Republic of Korea.
Insights
High-sensitivity C-reactive protein (hsCRP) and mean platelet volume (MPV) predict adverse outcomes after percutaneous coronary intervention (PCI). Elevated levels of both hsCRP and MPV are additively associated with a higher risk of major adverse cardiac and cerebrovascular events (MACCE).
Area of Science:
- Cardiology
- Biomarkers
- Interventional Cardiology
Background:
- Percutaneous coronary intervention (PCI) is a common procedure for treating coronary artery disease.
- Identifying reliable biomarkers to predict adverse outcomes post-PCI is crucial for patient management.
- High-sensitivity C-reactive protein (hsCRP) and mean platelet volume (MPV) are potential inflammatory and platelet activation markers.
Purpose of the Study:
- To investigate the relationship between hsCRP and MPV levels and the occurrence of major adverse cardiac and cerebrovascular events (MACCE) after PCI.
- To determine if hsCRP and MPV can serve as predictive markers for adverse outcomes in patients undergoing PCI.
Main Methods:
- A cohort of 372 patients undergoing PCI was analyzed.
- hsCRP and MPV levels were measured, with cut-off values determined by receiver operating characteristic (ROC) curve analysis (hsCRP: 0.31 mg/dl, MPV: 8.00 fl).
- Kaplan-Meier analysis and assessment of the association with MACCE (cardiac death, MI, TVR, ischemic stroke, stent thrombosis) were performed over a mean follow-up of 25.8 months.
Main Results:
- Patients with high hsCRP (≥0.31 mg/dl) and high MPV (>8.00 fl) exhibited significantly higher rates of cardiac death and MACCE compared to those with lower levels.
- Both high hsCRP and high MPV were independently associated with an increased risk of MACCE.
- An additive association was observed, where combined high hsCRP and MPV levels further increased the risk of MACCE.
Conclusions:
- hsCRP and MPV are valuable predictive markers for major adverse cardiac and cerebrovascular events following percutaneous coronary intervention.
- These biomarkers demonstrate an additive effect, indicating that elevated levels of both hsCRP and MPV significantly heighten the risk of adverse outcomes post-PCI.
Abstract:
This study was designed to establish the relationship of high-sensitivity C-reactive protein (hsCRP) and mean platelet volume (MPV) with the development of adverse outcomes after percutaneous coronary intervention (PCI). hsCRP levels and MPV were analysed in 372 patients who underwent PCI, with the primary endpoint as major adverse cardiac and cerebrovascular events (MACCE): a composite of cardiac death, myocardial infarction (MI), target vessel revascularization (TVR), ischemic stroke and stent thrombosis. During the follow-up period (mean, 25.8 months), there were 21 cardiac deaths, 10 MIs including four stent thrombosis events, seven ischemic strokes and 29 TVRs. The hsCRP cut-off level was set at 0.31 mg/dl using the receiver operating characteristic curve to differentiate between the groups with and without MACCE. The MPV cut-off level was set at 8.00 fl by the receiver operating characteristic curve to differentiate between the groups with and without MACCE. A Kaplan-Meier analysis revealed that the high hsCRP group (≥0.31 mg/dl) had a significantly higher cardiac death and MACCE rate than the low hsCRP group (<0.31 mg/dl), and the high MPV group (>8.00 fl) had a significantly higher cardiac death and MACCE rate than the low MPV group (≤8.00 fl). Furthermore, the high hsCRP and MPV groups were significantly associated with an increased risk of MACCE. These results show that hsCRP and MPV are predictive markers after PCI for MACCE; they are also additively associated with a higher risk of MACCE.
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