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Photodynamic Therapy with Blended Conducting Polymer/Fullerene Nanoparticle Photosensitizers
Published on: October 28, 2015
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Site-selective multi-porphyrin attachment enables the formation of a next-generation antibody-based photodynamic
Antoine Maruani1, Huguette Savoie, Francesca Bryden
1Department of Chemistry, University College London, 20 Gordon Street, London, WC1H 0AJ, UK. v.chudasama@ucl.ac.uk.
Chemical Communications (Cambridge, England)
|September 5, 2015
Abstract:
Herein we present a significant step towards next-generation antibody-based photodynamic therapeutics. Site-selective modification of a clinically relevant monoclonal antibody, with a serum-stable linker bearing a strained alkyne, allows for the controlled Cu-free "click" assembly of an in vitro active antibody-based PDT agent using a water soluble azide porpyhrin.
