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Occupation and Risk of Non-Hodgkin Lymphoma and Its Subtypes: A Pooled Analysis from the InterLymph Consortium
Andrea 't Mannetje1, Anneclaire J De Roos, Paolo Boffetta
1Centre for Public Health Research, Massey University, Wellington Campus, Wellington, New Zealand.
Environmental Health Perspectives
|September 5, 2015
Summary
Farming, hairdressing, and textile occupations are linked to an increased risk of non-Hodgkin lymphoma (NHL). Specific subtypes of NHL may be associated with women's hairdresser and textile worker roles.
Area of Science:
- Epidemiology
- Occupational Health
- Hematology
Background:
- Occupational exposures are linked to non-Hodgkin lymphoma (NHL) risk, but findings are inconsistent.
- Previous studies suggest associations between certain jobs and NHL, necessitating further investigation.
Purpose of the Study:
- To investigate the occupational risk of developing NHL and its common subtypes.
- To focus on specific occupations with a priori interest in relation to NHL risk.
Main Methods:
- A pooled analysis of 10,046 NHL cases and 12,025 controls from 10 international studies.
- Harmonized occupational coding using ISCO-1968, grouping occupations into 25 a priori categories.
- Calculated adjusted odds ratios for NHL and four subtypes: DLBCL, FL, CLL/SLL, and PTCL.
Main Results:
- Confirmed associations between NHL and farming, hairdressing, charworking/cleaning, spray-painting, electrical wiring, and carpentry.
- Observed increased NHL risk for field crop/vegetable farm workers (OR=1.26) and general farm workers (OR=1.19).
- Identified subtype-specific associations, including DLBCL and CLL/SLL with women's hairdressers, and DLBCL and PTCL with textile workers.
Conclusions:
- Pooled analysis supports links between farming, hairdressing, and textile industry exposures and NHL risk.
- Findings suggest that occupational exposures in hairdressing and textile industries may be associated with specific NHL subtypes.