Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Integrative proteomics and lipidomics reveals dual roles for lipid droplets in the host cell antiviral response.

Nature communications·2026
Same author

Trk1 potassium transport is crucial for effective <i>Candidozyma auris</i> skin colonization.

Proceedings of the National Academy of Sciences of the United States of America·2026
Same author

A model-based prion vaccine protects a transgenic mouse line carrying a Gerstmann-Sträussler-Scheinker disease mutation.

Acta neuropathologica·2026
Same author

Quadriceps mitochondrial DNA quantity, quality, and gene expression after 2 years of calorie restriction: exploratory results from the CALERIE trial.

GeroScience·2026
Same author

CDK9 interacts with a RanGTP-importin-β complex to regulate erythroid enucleation.

Journal of cell science·2026
Same author

Spatial and Temporal Patterns of Prion Gene Variation Are Consistent With a Response to Chronic Wasting Disease-Induced Selection in Wild White-Tailed Deer.

Ecology and evolution·2025

Related Experiment Video

Updated: Apr 4, 2026

Assessing Transmissible Spongiform Encephalopathy Species Barriers with an In Vitro Prion Protein Conversion Assay
11:41

Assessing Transmissible Spongiform Encephalopathy Species Barriers with an In Vitro Prion Protein Conversion Assay

Published on: March 10, 2015

8.3K

Transcriptomic responses to prion disease in rats.

Allen Herbst1, Anthony Ness2, Chad J Johnson3

  • 1Department of Agricultural, Food and Nutritional Science, Centre for Prions and Protein Folding Diseases, University of Alberta, Edmonton, AB, T6G 2M6, Canada.

BMC Genomics
|September 6, 2015
PubMed
Summary

Researchers studied prion diseases in rats, finding similar molecular responses to mice but with some gene expression differences. This comparative study enhances understanding of neurodegeneration and prion diseases.

More Related Videos

Investigating the Spreading and Toxicity of Prion-like Proteins Using the Metazoan Model Organism C. elegans
12:57

Investigating the Spreading and Toxicity of Prion-like Proteins Using the Metazoan Model Organism C. elegans

Published on: January 8, 2015

16.7K
Bioluminescence Imaging of Neuroinflammation in Transgenic Mice After Peripheral Inoculation of Alpha-Synuclein Fibrils
09:32

Bioluminescence Imaging of Neuroinflammation in Transgenic Mice After Peripheral Inoculation of Alpha-Synuclein Fibrils

Published on: April 13, 2017

9.0K

Related Experiment Videos

Last Updated: Apr 4, 2026

Assessing Transmissible Spongiform Encephalopathy Species Barriers with an In Vitro Prion Protein Conversion Assay
11:41

Assessing Transmissible Spongiform Encephalopathy Species Barriers with an In Vitro Prion Protein Conversion Assay

Published on: March 10, 2015

8.3K
Investigating the Spreading and Toxicity of Prion-like Proteins Using the Metazoan Model Organism C. elegans
12:57

Investigating the Spreading and Toxicity of Prion-like Proteins Using the Metazoan Model Organism C. elegans

Published on: January 8, 2015

16.7K
Bioluminescence Imaging of Neuroinflammation in Transgenic Mice After Peripheral Inoculation of Alpha-Synuclein Fibrils
09:32

Bioluminescence Imaging of Neuroinflammation in Transgenic Mice After Peripheral Inoculation of Alpha-Synuclein Fibrils

Published on: April 13, 2017

9.0K

Area of Science:

  • Neuroscience
  • Molecular Biology
  • Comparative Pathology

Background:

  • Prion diseases are fatal neurodegenerative conditions affecting mammals.
  • Mouse models are well-studied, but rat responses remain largely unknown.
  • This study introduces prion disease in rats for comparative analysis.

Purpose of the Study:

  • To characterize prion accumulation, pathology, and transcriptional changes in rats.
  • To compare molecular responses to prion infection between rats and mice.
  • To identify conserved and divergent gene expression patterns in prion disease.

Main Methods:

  • Generation of prion disease in laboratory rats via successive passage of mouse RML prions.
  • Monitoring prion accumulation and associated neuropathology.
  • Transcriptional profiling throughout the disease course.

Main Results:

  • Rat prions, pathology, and transcriptional changes were documented.
  • Comparative analysis revealed conserved molecular and cellular processes in rats and mice.
  • Significant variability in individual transcript deregulation was observed between species.

Conclusions:

  • The study details molecular responses to prion disease in rats.
  • Comparative transcriptomics highlight conserved and divergent pathways in neurodegeneration.
  • This approach deepens the understanding of prion diseases and mammalian neurodegeneration.