Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

MicroRNAs01:22

MicroRNAs

4.3K
MicroRNA (miRNA) are short, regulatory RNA transcribed from introns (non-coding regions of a gene) or intergenic regions (stretches of DNA present between genes). Several processing steps are required to form biologically active, mature miRNA. The initial transcript, called primary miRNA (pri-mRNA), base-pairs with itself, forming a stem-loop structure. Within the nucleus, an endonuclease enzyme, called Drosha, shortens the stem-loop structure into hairpin-shaped pre-miRNA. After the pre-miRNA...
4.3K
MicroRNAs01:22

MicroRNAs

24.7K
MicroRNA (miRNA) are short, regulatory RNA transcribed from introns—non-coding regions of a gene—or intergenic regions—stretches of DNA present between genes. Several processing steps are required to form biologically active, mature miRNA. The initial transcript, called primary miRNA (pri-mRNA), base-pairs with itself forming a stem-loop structure. Within the nucleus, an endonuclease enzyme, called Drosha, shortens the stem-loop structure into hairpin-shaped pre-miRNA. After...
24.7K
MicroRNAs01:22

MicroRNAs

12.1K
12.1K
Structure and Function of Platelets01:18

Structure and Function of Platelets

5.4K
The cell fragments known as platelets are disc-shaped, with an average diameter of about 3 μm and a thickness of roughly 1 μm. They play a crucial role in the body's vascular clotting system, which also involves plasma proteins, blood cells, and blood vessel tissues.
Platelets are continually replenished, circulating in the bloodstream for 9-12 days before being removed by phagocytes, primarily in the spleen. A microliter of circulating blood contains between 150,000 and 450,000...
5.4K
piRNA - Piwi-interacting RNAs02:57

piRNA - Piwi-interacting RNAs

7.9K
PIWI-interacting RNAs, or piRNAs, are the most abundant short non-coding RNAs. More than 20,000 genes have been found in humans that code for piRNAs while only 2000 genes have been found for miRNAs. piRNAs can act at the transcriptional and post-transcriptional levels and have a vital role in silencing transposable elements present in germ cells. They are also involved in epigenetic silencing and activation. Previously, they were thought to function only in germ cells but new evidence suggests...
7.9K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Polypharmacy burden and incident epilepsy among older adults in the United States.

Epilepsia open·2026
Same author

Prenatal BPA exposure perturbs RNA-binding protein-mediated splicing regulation and synaptogenesis in the developing cerebellum in a sex-dependent manner.

Biology of sex differences·2026
Same author

Genome-Wide DNA Methylation Profiling of Peripheral Blood Mononuclear Cells Reveals Epigenetic Signatures in Autism Spectrum Disorder.

International journal of molecular sciences·2026
Same author

Integrating Cancer Registry and Medicaid Data for Survivorship-Focused Research.

Journal of registry management·2026
Same author

Neurological Effects of <i>Cleistocalyx nervosum</i> var. <i>paniala</i> Berry on Hippocampal Transcriptome, Neuritogenesis, and Synaptogenesis.

Nutrients·2026
Same author

Prenatal bisphenol A exposure perturbs sex-dependent transcriptomic regionalization of autism-associated genes in the developing brain.

Biology direct·2026
Same journal

Assessment of CTLA-4, LAG-3, and TIM-3 Expression in Pediatric Patients With β-Thalassemia Major and Their Association With Alloimmunization.

Transfusion medicine reviews·2026
Same journal

A Reply to "Beyond Implementation: The Need for Validation, Equity, and Real-World Accountability in AI for Transfusion Medicine".

Transfusion medicine reviews·2026
Same journal

Beyond Implementation: The Need for Validation, Equity, and Real-World Accountability in AI for Transfusion Medicine.

Transfusion medicine reviews·2026
Same journal

Trust Over Knowledge: Rethinking Donor Iron Supplementation Strategies in Modern Blood Services-Authors' reply.

Transfusion medicine reviews·2026
Same journal

The Effect of Stress Ball and Music on Anxiety, Distress, and Pain Levels During Platelet Apheresis Donation: Randomized Controlled Trial.

Transfusion medicine reviews·2026
Same journal

Therapeutic Plateletpheresis for Thrombocytosis: Critical Analytic Reviews and Original Multicenter Experience.

Transfusion medicine reviews·2026
See all related articles

Related Experiment Video

Updated: Apr 4, 2026

Genome-wide Screen for miRNA Targets Using the MISSION Target ID Library
08:40

Genome-wide Screen for miRNA Targets Using the MISSION Target ID Library

Published on: April 6, 2012

18.1K

Platelet MicroRNAs: An Overview.

Neetu Dahiya1, Tewarit Sarachana2, Long Vu1

  • 1Section of Cell Biology, Laboratory of Cellular Hematology, Division of Hematology Research and Review, Center for Biologics Evaluation and Research, US Food and Drug Administration, Silver Spring, MD.

Transfusion Medicine Reviews
|September 6, 2015
PubMed
Summary
This summary is machine-generated.

MicroRNAs (miRNAs) regulate gene expression in platelets, impacting function and disease. Emerging studies highlight their role in transfusion medicine, platelet disorders, and storage quality.

Keywords:
Blood disordersMicroRNAPlateletsSignaling pathways

More Related Videos

A Complete Pipeline for Isolating and Sequencing MicroRNAs, and Analyzing Them Using Open Source Tools
09:29

A Complete Pipeline for Isolating and Sequencing MicroRNAs, and Analyzing Them Using Open Source Tools

Published on: August 21, 2019

8.0K
Identifying Targets of Human microRNAs with the LightSwitch Luciferase Assay System using 3'UTR-reporter Constructs and a microRNA Mimic in Adherent Cells
07:19

Identifying Targets of Human microRNAs with the LightSwitch Luciferase Assay System using 3'UTR-reporter Constructs and a microRNA Mimic in Adherent Cells

Published on: September 28, 2011

37.0K

Related Experiment Videos

Last Updated: Apr 4, 2026

Genome-wide Screen for miRNA Targets Using the MISSION Target ID Library
08:40

Genome-wide Screen for miRNA Targets Using the MISSION Target ID Library

Published on: April 6, 2012

18.1K
A Complete Pipeline for Isolating and Sequencing MicroRNAs, and Analyzing Them Using Open Source Tools
09:29

A Complete Pipeline for Isolating and Sequencing MicroRNAs, and Analyzing Them Using Open Source Tools

Published on: August 21, 2019

8.0K
Identifying Targets of Human microRNAs with the LightSwitch Luciferase Assay System using 3'UTR-reporter Constructs and a microRNA Mimic in Adherent Cells
07:19

Identifying Targets of Human microRNAs with the LightSwitch Luciferase Assay System using 3'UTR-reporter Constructs and a microRNA Mimic in Adherent Cells

Published on: September 28, 2011

37.0K

Area of Science:

  • Molecular Biology
  • Hematology
  • Transfusion Medicine

Background:

  • MicroRNAs (miRNAs) are noncoding RNAs regulating gene expression.
  • Platelet miRNA levels are altered in storage and disease.
  • Experimental validation of miRNA roles in platelets is emerging.

Purpose of the Study:

  • Review emerging human platelet miRNA studies.
  • Emphasize miRNA roles in transfusion medicine.
  • Highlight relevance to platelet signaling, disorders, and storage.

Main Methods:

  • Bioinformatics-based miRNA target predictions.
  • Experimental validation of miRNA:mRNA interactions.
  • Review of current human platelet miRNA research.

Main Results:

  • miRNAs influence platelet signaling pathways.
  • miRNAs are potential markers for platelet disorders.
  • miRNAs may indicate platelet storage quality and treatment effects.

Conclusions:

  • Platelet miRNAs are crucial in transfusion medicine.
  • Further research can elucidate miRNA roles in platelet function and disease.
  • miRNAs offer potential as biomarkers for platelet quality and storage.