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NUT expression in primary lung tumours
Marius Lund-Iversen1,2, Krystyna Kotanska Grøholt3, Åslaug Helland4
1Department of Pathology, Oslo University Hospital, Radiumhospitalet 0310, Oslo, Norway. mlundive@ous-hf.no.
Diagnostic Pathology
|September 6, 2015
Summary
Nuclear protein in testis (NUT) midline carcinomas (NMC) are rare. Researchers found no NUT protein expression in 483 lung carcinoma and carcinoid tumor specimens, suggesting NUT gene rearrangement is not relevant in these primary lung cancers.
Area of Science:
- Oncology
- Molecular Pathology
Background:
- Nuclear protein in testis (NUT) midline carcinomas (NMC) are rare, aggressive neoplasms.
- NMC are characterized by NUT-fusion proteins due to chromosome 15;19 translocations.
- NMC typically occur in midline structures but have been reported elsewhere.
Purpose of the Study:
- To investigate the presence of NUT protein in primary lung carcinomas and carcinoid tumors.
- To determine the relevance of NUT gene rearrangement in these pulmonary neoplasms.
Main Methods:
- Immunohistochemistry was used to detect NUT protein expression.
- Specimens from 519 surgically resected lung carcinomas and carcinoid tumors were analyzed.
- Normal testis and confirmed NMCs served as positive controls.
Main Results:
- All 483 evaluable lung carcinoma and carcinoid tumor cases were negative for NUT protein expression.
- Specific tumor types analyzed included adenocarcinomas, squamous cell carcinomas, large cell carcinomas, small cell carcinomas, undifferentiated carcinomas, and carcinoids.
Conclusions:
- NUT gene rearrangement does not appear to be a significant factor in primary pulmonary carcinomas.
- NUT protein expression is not detected in carcinoid tumors of the lung.
