Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

The Tumor Microenvironment02:17

The Tumor Microenvironment

8.2K
Every normal cell or tissue is embedded in a complex local environment called stroma, consisting of different cell types, a basal membrane, and blood vessels. As normal cells mutate and develop into cancer cells, their local environment also changes to allow cancer progression. The tumor microenvironment (TME) consists of a complex cellular matrix of stromal cells and the developing tumor. The cross-talk between cancer cells and surrounding stromal cells is critical to disrupt normal tissue...
8.2K
The Tumor Microenvironment02:17

The Tumor Microenvironment

3.1K
3.1K
Tumor Immunotherapy01:27

Tumor Immunotherapy

2.3K
Immunotherapy is a treatment that boosts or manipulates the immune system to fight diseases, including cancer. For instance, by stimulating an immune response through vaccinations against viruses that cause cancers, like hepatitis B virus and human papillomavirus, these diseases can be prevented. Nonetheless, some cancer cells can avoid the immune system due to their rapid mutation and division. The immune response to many cancers involves three phases: elimination, equilibrium, and escape.
2.3K
Targeted Cancer Therapies02:57

Targeted Cancer Therapies

9.1K
The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against...
9.1K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Nano-micro Combination: Overcoming Dual Intranasal Barriers to Elicit a Comprehensive Immune Response.

ACS applied materials & interfaces·2026
Same author

SERS nanotag coatings and surface layers: Critical yet underemphasized contributions to probe stability, sensitivity, and biological target specificity.

Advances in colloid and interface science·2026
Same author

Interpretable Wavelet-CNN for Accurate Serum Raman Lung Cancer Diagnosis under Leakage-Safe, Patient-Level Splits.

Analytical chemistry·2026
Same author

Self-adjuvanting α-helical polypeptide simultaneously delivers neoantigen mRNAs and activates dendritic cells to eradicate tumors.

Proceedings of the National Academy of Sciences of the United States of America·2026
Same author

Fabrication of Tissue Constructs and Organoids Using Electrospun Micro/Nanofibers.

Chemical reviews·2026
Same author

Machine-Learning-Enabled Raman Spectroscopy Refines Indocyanine Green Fluorescence Boundaries for Precise Glioblastoma Margin Delineation.

Research (Washington, D.C.)·2026

Related Experiment Video

Updated: Apr 4, 2026

Magnetic-, Acoustic-, and Optical-Triple-Responsive Microbubbles for Magnetic Hyperthermia and Pothotothermal Combination Cancer Therapy
09:01

Magnetic-, Acoustic-, and Optical-Triple-Responsive Microbubbles for Magnetic Hyperthermia and Pothotothermal Combination Cancer Therapy

Published on: May 22, 2020

3.6K

Stimuli-responsive nanoparticles for targeting the tumor microenvironment.

Jinzhi Du1, Lucas A Lane1, Shuming Nie2

  • 1Department of Biomedical Engineering, Emory University and Georgia Institute of Technology, Atlanta, GA 30322, United States; Department of Chemistry, Emory University and Georgia Institute of Technology, Atlanta, GA 30322, United States.

Journal of Controlled Release : Official Journal of the Controlled Release Society
|September 6, 2015
PubMed
Summary

Smart nanoparticles are engineered to target solid tumors by activating in acidic and hypoxic tumor microenvironments. This approach enhances drug delivery and overcomes tumor heterogeneity for broad applications in cancer nanomedicine.

Keywords:
HypoxiaMatrix metalloproteinasesNanomedicineTumor heterogeneityTumor microenvironmentpH

More Related Videos

Inducing Targeted Mild Hyperthermia in Murine Tumor Models through Photothermal Conversion of Near-infrared Light by Intratumoral Gold Nanorods
09:23

Inducing Targeted Mild Hyperthermia in Murine Tumor Models through Photothermal Conversion of Near-infrared Light by Intratumoral Gold Nanorods

Published on: October 10, 2025

1.7K
Polymalic Acid-based Nano Biopolymers for Targeting of Multiple Tumor Markers: An Opportunity for Personalized Medicine?
14:20

Polymalic Acid-based Nano Biopolymers for Targeting of Multiple Tumor Markers: An Opportunity for Personalized Medicine?

Published on: June 13, 2014

17.2K

Related Experiment Videos

Last Updated: Apr 4, 2026

Magnetic-, Acoustic-, and Optical-Triple-Responsive Microbubbles for Magnetic Hyperthermia and Pothotothermal Combination Cancer Therapy
09:01

Magnetic-, Acoustic-, and Optical-Triple-Responsive Microbubbles for Magnetic Hyperthermia and Pothotothermal Combination Cancer Therapy

Published on: May 22, 2020

3.6K
Inducing Targeted Mild Hyperthermia in Murine Tumor Models through Photothermal Conversion of Near-infrared Light by Intratumoral Gold Nanorods
09:23

Inducing Targeted Mild Hyperthermia in Murine Tumor Models through Photothermal Conversion of Near-infrared Light by Intratumoral Gold Nanorods

Published on: October 10, 2025

1.7K
Polymalic Acid-based Nano Biopolymers for Targeting of Multiple Tumor Markers: An Opportunity for Personalized Medicine?
14:20

Polymalic Acid-based Nano Biopolymers for Targeting of Multiple Tumor Markers: An Opportunity for Personalized Medicine?

Published on: June 13, 2014

17.2K

Area of Science:

  • Nanomedicine
  • Biomedical Engineering
  • Oncology

Background:

  • Delivering imaging and therapeutic agents to solid tumors remains a significant challenge in nanomedicine.
  • Solid tumors possess unique microenvironmental attributes, including acidity and hypoxia, which can be targeted for drug delivery.

Purpose of the Study:

  • To discuss the design and development of stimuli-responsive smart nanoparticles for targeting solid tumor microenvironments.
  • To explore how these nanoparticles can overcome challenges in tumor targeting and heterogeneity.

Main Methods:

  • Development of nanoparticles activated by specific tumor microenvironment conditions (acidic pH, enzymatic up-regulation, hypoxia).
  • Design of nanoparticles with a multi-stage process: vascular navigation, tumor site docking, and in-situ activation.
  • Combination of nanodelivery vehicle properties with small drug cargo diffusion and penetration characteristics.

Main Results:

  • Stimuli-responsive nanoparticles remain inactive in circulation but activate within the tumor microenvironment.
  • This strategy integrates favorable pharmacokinetics of nanoparticles with enhanced diffusion of smaller molecules.
  • Targeting tumor habitats rather than specific receptors offers a potential solution to tumor heterogeneity.

Conclusions:

  • Stimuli-responsive nanoparticles offer a promising strategy for targeted delivery of diagnostic and therapeutic agents to solid tumors.
  • This approach has the potential to overcome tumor heterogeneity, enabling applications across a broad range of solid tumor types.
  • The design allows for controlled activation within the tumor, minimizing off-target effects.