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Related Experiment Video

Updated: Apr 4, 2026

Adult Mouse DRG Explant and Dissociated Cell Models to Investigate Neuroplasticity and Responses to Environmental Insults Including Viral Infection

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N-myc downstream-regulated gene 2 in the nervous system: from expression pattern to function.

Kaifeng Lin¹, Anqi Yin², Libo Yao¹

¹Department of Biochemistry and Molecular Biology, The Fourth Military Medical University, Xi'an 710032, China.

Acta Biochimica Et Biophysica Sinica

|September 6, 2015

Summary

Human N-myc downstream-regulated gene 2 (NDRG2) is a key protein in brain astrocytes, influencing neurogenesis and nervous system diseases like neurodegeneration and glioblastoma.

Keywords:

NDRG2 astrocytes brain cell stress nervous system diseases

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Area of Science:

Neuroscience
Molecular Biology
Cell Biology

Background:

Human N-myc downstream-regulated gene 2 (NDRG2) is a multifunctional protein involved in cell proliferation, differentiation, transmembrane transport, and stress responses.
NDRG2 is primarily expressed in astrocytic cells across various regions of the mammalian brain.

Purpose of the Study:

To review the distribution and subcellular localization of NDRG2 in brain tissues.
To highlight the physiological functions of NDRG2 within the nervous system.
To discuss the roles of NDRG2 in the development of nervous system diseases.

Main Methods:

Literature review of studies on NDRG2.
Analysis of NDRG2 expression patterns in brain tissues.
Examination of NDRG2's involvement in neurogenesis and neurological disorders.

Main Results:

NDRG2 is predominantly found in astrocytes in the brain.
NDRG2 plays a significant role in regulating neurogenesis.
NDRG2 is implicated in the pathogenesis of neurodegenerative diseases, ischemia, and glioblastoma.

Conclusions:

NDRG2 is a crucial protein in the brain, particularly in astrocytes.
Understanding NDRG2's functions is vital for addressing nervous system diseases.
Further research into NDRG2 could lead to novel therapeutic strategies for neurological conditions.