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Five-year review of a UK 24 hour testing service for plasma ethylene glycol and diethylene glycol
Loretta T Ford1, Jonathan D Berg2
1Department Clinical Biochemistry, City Hospital, Birmingham, UK Loretta.Ford@nhs.net.
Background:
We present a 5-year review of our UK service for plasma ethylene glycol and diethylene glycol determination in cases of acute poisoning.
Methods:
Ethylene glycol and diethylene glycol have been measured on all samples received for screening for toxicity by gas chromatography-flame ionization detection over a five-year period. A detailed audit of the results has been undertaken.
Results:
In this period, we received 811 requests, 56% were for first-time screening and 44% repeat analysis where a positive sample has already been received. Of the first-time screen samples, 33.5% screened positive for glycol poisoning. The mean positive ethylene glycol concentration was 1204 mg/L (range 31 to 8666 mg/L). Diethylene glycol was present in 14% of ethylene glycol positive samples but never found alone.
Conclusions:
The data presented here suggest it is not essential to measure diethylene glycol since its inclusion is rarely likely to change patient management.
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