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No-Go'ing Back: Co-opting RVB-2 to Control HIV-1 Gene Expression and Immune Response
Valerie Le Sage1, Alessandro Cinti2, Andrew J Mouland3
1HIV-1 RNA Trafficking Laboratory, Lady Davis Institute at the Jewish General Hospital, Montréal, Québec, H3T 1E2, Canada.
Abstract:
Production of infectious HIV-1 particles requires viral envelope (Env) glycoprotein incorporation. Although, the precise mechanism remains elusive, interaction between Env and the matrix (MA) domain of Gag plays a central role. Work by Mu and colleagues demonstrates how the Env-MA interaction regulates gag mRNA stability and Gag expression levels.
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