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Updated: Apr 4, 2026

Improving High Viscosity Extrusion of Microcrystals for Time-resolved Serial Femtosecond Crystallography at X-ray Lasers
Published on: February 28, 2019
Using synchrotrons and XFELs for time-resolved X-ray crystallography and solution scattering experiments on
Matteo Levantino1, Briony A Yorke2, Diana Cf Monteiro3
1Department of Physics and Chemistry, University of Palermo, Palermo 90128, Italy.
Abstract:
Time-resolved structural information is key to understand the mechanism of biological processes, such as catalysis and signalling. Recent developments in X-ray sources as well as data collection and analysis methods are making routine time-resolved X-ray crystallography and solution scattering experiments a real possibility for structural biologists. Here we review the information that can be obtained from these techniques and discuss the considerations that must be taken into account when designing a time-resolved experiment.
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