[Changes in various lymphocyte subpopulations in the peripheral blood of patients with chronic uremia during...

The examination was carried out in a group of 20 patients with decadent renal failure (14 males and 6 females) from 16 to 51 years of age (average 32 years) undergoing the therapy of repeated haemodialysis (HD) during a period from 1.5 to 72 months. The HD procedure was performed by the use of the cuprophan dialyze (Gambro). The samples were taken on an empty stomach, before HD and then in the 20th 60th and 120th minute of HD. The absolute number of lymphocytes and their subpopulations were determined by means of rosette tests. In the patients with uraemia, the absolute number of lymphocytes and their subpopulations in the peripheral blood was significantly lower than in healthy persons selected appropriately with respect to sex and age. In the initial phase of HD the authors found a significant decrease in the absolute number of the whole population of lymphocytes, and also their sub-populations T, B, TM and an increase in the absolute number of subpopulation TG. These changes were of transient character and became normalized almost completely in the 120th minute of the procedure.