Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Barrett Esophagus-II: Clinical Manifestations and Management01:21

Barrett Esophagus-II: Clinical Manifestations and Management

1.5K
Individuals with Barrett's esophagus are often asymptomatic, but they may experience symptoms commonly associated with GERD, such as heartburn and acid regurgitation. Additional symptoms can include difficulty swallowing, chest pain, unintentional weight loss, blood in the stool (which may appear black, tarry, or bloody), and episodes of vomiting.
To diagnose Barrett's esophagus, healthcare providers often recommend an endoscopy for those showing symptoms of acid reflux. The procedure...
1.5K
Esophageal Strictures-I: Introduction01:30

Esophageal Strictures-I: Introduction

1.2K
Esophageal strictures involve abnormal narrowing or tightening of the esophagus. They vary in length and severity, ranging from mild constriction to complete obstruction, and are classified as benign (noncancerous) or malignant (cancerous).
Etiology
The primary cause of esophageal strictures is long-standing gastroesophageal reflux disease (GERD), accounting for about 70 to 80% of adult cases. Chronic acid reflux can lead to injury and scarring of the esophageal lining, culminating in...
1.2K
Gastroesophageal Reflux Disease II: Clinical Features and Management01:29

Gastroesophageal Reflux Disease II: Clinical Features and Management

1.1K
Gastroesophageal reflux disease, or GERD, is a persistent medical condition that affects many individuals worldwide. Its clinical manifestations can vary greatly, making diagnosis and management challenging for healthcare professionals. The following is a comprehensive overview of the clinical manifestations, assessment, and management strategies for GERD.
Clinical Manifestations
GERD presents itself in a multitude of ways, with symptoms varying from person to person. The hallmark symptoms are...
1.1K
Barrett Esophagus-I: Introduction01:21

Barrett Esophagus-I: Introduction

1.3K
Barrett's esophagus is a medical condition where the esophageal mucosa is significantly damaged by stomach acid or other digestive fluids, often due to long-term exposure associated with gastroesophageal reflux disease (GERD). In GERD, a weakened or abnormally relaxed lower esophageal sphincter allows stomach acid to flow persistently into the esophagus.
This constant acid exposure transforms the esophagus's pink mucosal lining (stratified squamous epithelium) into a type of lining more...
1.3K
Esophageal Strictures-II: Clinical Features and Management01:26

Esophageal Strictures-II: Clinical Features and Management

928
Patients with esophageal strictures often experience a range of symptoms. Initially, they may have difficulty swallowing solid foods, which can progress to include liquids. Additional symptoms may involve chest pain or discomfort, regurgitating food and fluids, heartburn, unintentional weight loss, coughing or choking during meals, and hoarseness.
Healthcare providers should gather a comprehensive medical history and conduct a physical examination for diagnosis. If esophageal stricture is...
928
Gastroesophageal Reflux Disease I: Meaning and Pathophysiology01:29

Gastroesophageal Reflux Disease I: Meaning and Pathophysiology

2.1K
Gastroesophageal Reflux Disease (GERD) involves the recurrent backflow of the stomach or duodenal contents into the esophagus, leading to troublesome symptoms and potential esophageal mucosal damage. Although GERD is often referred to as a disease, it is more accurately described as a syndrome, as it encompasses a range of symptoms and complications rather than a singular pathological entity, impacting a large number of individuals as the most prevalent upper gastrointestinal problem. Roughly...
2.1K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Dupilumab Improves Endoscopic Features in Children Aged 1-11 Years With Eosinophilic Esophagitis: EoE KIDS Study Results.

The American journal of gastroenterology·2026
Same author

Impacts shaped Earth's first continents.

Science (New York, N.Y.)·2026
Same author

Dupilumab versus placebo in adults and adolescents with eosinophilic gastritis (DEGAS): a double-blind, placebo-controlled, phase 2, multicentre, randomised controlled trial.

The lancet. Gastroenterology & hepatology·2026
Same author

Comparing Quality of Life in Rectal Cancer Survivors Managed With Watch-and-Wait Versus Surgery.

Clinical colorectal cancer·2026
Same author

Effect of polymyxin resistance evolution on the fitness costs of Acinetobacter baumannii and the underlying mechanisms of polymyxin resistance.

Scientific reports·2026
Same author

Baseline characteristics, treatment patterns, and long-term outcomes in patients with eosinophilic esophagitis initiating dupilumab in routine clinical practice: study protocol of a phase IV, prospective, observational, multicenter registry (EDESIA).

Therapeutic advances in gastroenterology·2026

Related Experiment Video

Updated: Apr 4, 2026

Author Spotlight: Investigating the Pathophysiology of Eosinophilic Esophagitis
03:23

Author Spotlight: Investigating the Pathophysiology of Eosinophilic Esophagitis

Published on: May 10, 2024

1.6K

Longitudinal Perspective on Managing Refractory Eosinophilic Esophagitis.

John Leung1, Raman Mehrzad2, Navneet Virk Hundal3

  • 1Food Allergy Center, Massachusetts General Hospital, Boston, Mass; Center of Immunology and Inflammatory Disease, Massachusetts General Hospital, Boston, Mass; Food Allergy Center at Tufts Medical Center and Floating Hospital, Boston, Mass.

The Journal of Allergy and Clinical Immunology. in Practice
|September 7, 2015
PubMed
Summary

Many patients with eosinophilic esophagitis (EoE) not achieving initial remission can still achieve histological remission with tailored rescue treatments. No specific clinical features predict response to these subsequent eosinophilic esophagitis therapies.

Keywords:
Eosinophilic esophagitisManagementRefractoryTreatment

More Related Videos

Simultaneous Laryngopharyngeal and Conventional Esophageal pH Monitoring
06:46

Simultaneous Laryngopharyngeal and Conventional Esophageal pH Monitoring

Published on: December 14, 2020

3.5K
Conditional Reprogramming of Pediatric Human Esophageal Epithelial Cells for Use in Tissue Engineering and Disease Investigation
10:15

Conditional Reprogramming of Pediatric Human Esophageal Epithelial Cells for Use in Tissue Engineering and Disease Investigation

Published on: March 22, 2017

7.4K

Related Experiment Videos

Last Updated: Apr 4, 2026

Author Spotlight: Investigating the Pathophysiology of Eosinophilic Esophagitis
03:23

Author Spotlight: Investigating the Pathophysiology of Eosinophilic Esophagitis

Published on: May 10, 2024

1.6K
Simultaneous Laryngopharyngeal and Conventional Esophageal pH Monitoring
06:46

Simultaneous Laryngopharyngeal and Conventional Esophageal pH Monitoring

Published on: December 14, 2020

3.5K
Conditional Reprogramming of Pediatric Human Esophageal Epithelial Cells for Use in Tissue Engineering and Disease Investigation
10:15

Conditional Reprogramming of Pediatric Human Esophageal Epithelial Cells for Use in Tissue Engineering and Disease Investigation

Published on: March 22, 2017

7.4K

Area of Science:

  • Gastroenterology
  • Immunology
  • Pediatric Medicine

Background:

  • A significant proportion of patients with eosinophilic esophagitis (EoE) do not achieve histological remission after initial treatment.
  • This study investigates whether these treatment-refractory patients represent a distinct clinical subgroup.

Purpose of the Study:

  • To analyze treatment outcomes for eosinophilic esophagitis (EoE) in a predominantly pediatric patient population.
  • To identify potential clinical predictors of treatment response in EoE.

Main Methods:

  • A retrospective review of 100 consecutive eosinophilic esophagitis (EoE) cases treated at Massachusetts General Hospital since 2007.
  • Histological remission defined as a peak esophageal eosinophil count <10 eosinophils per high-power field (hpf).

Main Results:

  • Initial treatment response rates were 67% for dietary therapy and 56% for topical glucocorticoids.
  • Among 34 patients failing initial treatment, 54% responded to second-line therapies, and an additional 18% responded to further treatments.
  • Overall response rates improved from 65% with initial treatment to 80% with multiple treatment strategies.
  • Patients responding to initial treatment presented with more symptoms and endoscopic abnormalities.
  • No distinct clinical features differentiated patients who failed both initial and rescue therapy from those who responded to rescue therapy.

Conclusions:

  • Individualized rescue treatments can lead to histological remission in over half of eosinophilic esophagitis (EoE) patients who do not respond to initial therapy.
  • No clinical characteristics were identified to predict a successful response to rescue treatments for EoE.