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Prudent diet may attenuate the adverse effects of Western diet on cognitive decline
Behnaz Shakersain1, Giola Santoni1, Susanna C Larsson2
1Aging Research Center, Center for Alzheimer Research, Department of Neurobiology, Care Sciences and Society, Karolinska Institutet and Stockholm University, Stockholm, Sweden.
Introduction:
The influence of mixed dietary patterns on cognitive changes is unknown.
Methods:
A total of 2223 dementia-free participants aged ≥60 were followed up for 6 years to examine the impact of dietary patterns on cognitive decline. Mini-mental state examination (MMSE) was administered. Diet was assessed by a food frequency questionnaire. By factor analysis, Western and prudent dietary patterns emerged. Mixed-effect models for longitudinal data with repeated measurements were used.
Results:
Compared with the lowest adherence to each pattern, the highest adherence to prudent pattern was related to less MMSE decline (β = 0.106, P = .011), whereas the highest adherence to Western pattern was associated with more MMSE decline (β = -0.156, P < .001). The decline associated with Western diet was attenuated when accompanied by high adherence to prudent pattern.
Discussion:
High adherence to prudent diet may diminish the adverse effects of high adherence to Western diet on cognitive decline.
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