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MicroRNA-based Regulation of Picornavirus Tropism
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MicroRNA-based Regulation of Picornavirus Tropism

Published on: February 6, 2017

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The role of microRNAs in enteroviral infections

Jing Wu1, Li Shen2, Jianguo Chen3

  • 1School of Medicine, Jiangsu University, Zhenjiang, Jiangsu Province, China.

The Brazilian Journal of Infectious Diseases : an Official Publication of the Brazilian Society of Infectious Diseases
|September 7, 2015
PubMed

Insights

MicroRNAs significantly impact enterovirus infections by altering viral and host gene expression. This review details how these small RNAs influence enteroviral pathogenesis and replication.

Area of Science:

  • Virology
  • Molecular Biology
  • Genetics

Background:

  • Enteroviruses (Picornaviridae family) are RNA viruses causing diseases like poliomyelitis and meningitis.
  • MicroRNAs (miRNAs) are small, noncoding RNAs regulating gene expression.
  • Emerging research highlights miRNAs' crucial role in enteroviral infections.

Purpose of the Study:

  • To review the multifaceted roles of microRNAs in enteroviral infections.
  • To elucidate the interplay between enteroviruses and host microRNA machinery.
  • To summarize how miRNAs modulate viral replication and pathogenesis.

Main Methods:

  • Literature review of studies on microRNAs and enteroviruses.
  • Analysis of experimental data on miRNA expression changes during infection.
  • Synthesis of findings on miRNA-mediated regulation of viral and host genes.

Main Results:

  • Enteroviral infections significantly alter cellular microRNA expression profiles.
  • MicroRNAs can suppress or enhance enteroviral replication and pathogenesis.
  • Specific miRNAs target viral or host genes to modulate infection outcomes.

Conclusions:

  • MicroRNAs are key players in the complex host-pathogen interactions during enteroviral infections.
  • Understanding miRNA-virus interactions offers potential therapeutic targets.
  • Further research is needed to fully elucidate the regulatory networks involved.
Keywords:
EnterovirusInfectionMicroRNAs

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