Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

[Autoimmune chronic hepatitis in children].

A Nałecz, W Janowicz, J Pawłowska

    Wiadomosci Lekarskie (Warsaw, Poland : 1960)
    |July 1, 1989
    PubMed
    Summary

    Autoimmune chronic hepatitis in children is difficult to treat, with prednisone failing to achieve full remission in observed cases. This chronic liver disease often progresses to cirrhosis despite treatment.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Long-Term Follow-Up of Patients With Transaldolase Deficiency.

    Journal of inherited metabolic disease·2026
    Same author

    Does total neoadjuvant therapy improve overall survival in rectal cancer? Interpretation of the PRODIGE-23 and other studies.

    Annals of oncology : official journal of the European Society for Medical Oncology·2024
    Same author

    Fungal Planet description sheets: 1614-1696.

    Fungal systematics and evolution·2024
    Same author

    Fungal Planet description sheets: 1478-1549.

    Persoonia·2024
    Same author

    Does the RAPIDO trial suggest a benefit of post-operative chemotherapy after preoperative chemoradiation in rectal cancer? No, it does not.

    ESMO open·2023
    Same author

    Fungal Planet description sheets: 1284-1382.

    Persoonia·2023

    Area of Science:

    • Hepatology
    • Pediatric Gastroenterology
    • Autoimmune Diseases

    Context:

    • Autoimmune chronic hepatitis (ACH) is a severe liver condition with unknown causes.
    • Pediatric ACH presents diagnostic and management challenges.
    • Long-term prognosis of ACH can include cirrhosis.

    Purpose:

    • To describe the clinical characteristics and treatment outcomes of autoimmune chronic hepatitis in children.
    • To evaluate the efficacy of prednisone treatment in pediatric ACH.
    • To correlate clinical findings with histological and biochemical markers.

    Summary:

    • Eleven children (10 girls, 1 boy; ages 8-16) with ACH were observed over 4 years.
    • Diagnosis involved histology, clinical symptoms, and biochemistry, revealing elevated gamma-globulin, immunoglobulin G, bile acids, and A1AT activity.
    • Prednisone treatment did not achieve full remission in any patient after 2 years, with 5 cases showing persistent disease progression.

    Impact:

    • Highlights the chronic and progressive nature of pediatric ACH.
    • Underscores the limitations of current corticosteroid therapy in achieving complete remission.
    • Emphasizes the need for further research into effective long-term management strategies for ACH in children.

    Related Experiment Videos