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Related Concept Videos

Vitamins01:30

Vitamins

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Vitamins, derived from the Latin word for life, are essential organic substances required in small quantities for optimal growth and overall well-being. Unlike other organic nutrients, vitamins don't act as sources of energy or building materials but rather facilitate these nutrients' utilization by the body. Vitamins are predominantly coenzymes, assisting enzymes in specific chemical actions, like the oxidation of glucose for energy involving B vitamins. Most vitamins are not produced...
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The ability of a drug to produce structural deformations and functional abnormalities in the developing embryo or the fetus is called teratogenicity, and the drug producing this effect is known as a teratogen. Teratogenic effects include stillbirth, miscarriage, intrauterine growth restriction, and neurocognitive delay. A teratogen may affect the embryo at different stages of development, which is important in determining the type and extent of the damage. During blastocyst formation, the early...
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The skin plays a crucial role in the synthesis of vitamin D, a vital nutrient for various physiological processes in the body. Vitamin D is unique because it can be synthesized in the skin through a series of chemical reactions triggered by exposure to ultraviolet B (UVB) radiation from sunlight.
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Oral anticoagulants are vital tools in preventing and treating blood clotting disorders. This diverse class of medications can be categorized as vitamin K antagonists, exemplified by warfarin, and direct thrombin inhibitors (DTIs), such as dabigatran, as well as factor Xa inhibitors, including rivaroxaban.
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Related Experiment Video

Updated: Apr 4, 2026

Author Spotlight: Studying the Impact of Maternal Dietary Deficiencies on Long-Term Offspring Health Outcomes
03:19

Author Spotlight: Studying the Impact of Maternal Dietary Deficiencies on Long-Term Offspring Health Outcomes

Published on: June 28, 2024

841

Vitamin E supplementation in pregnancy.

Alice Rumbold1, Erika Ota, Hiroyuki Hori

  • 1The Robinson Research Institute, The University of Adelaide, Ground Floor, Norwich Centre, 55 King William Road, Adelaide, NT, Australia, SA 5006.

The Cochrane Database of Systematic Reviews
|September 8, 2015
PubMed
Summary
This summary is machine-generated.

Vitamin E supplementation in pregnancy, combined with other nutrients, did not prevent stillbirth, neonatal death, or pre-eclampsia. It may reduce placental abruption risk but increases abdominal pain and term prelabour rupture of membranes (PROM).

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Area of Science:

  • Obstetrics and Gynecology
  • Nutritional Science
  • Evidence-Based Medicine

Background:

  • Oxidative stress during pregnancy can lead to complications like pre-eclampsia.
  • Vitamin E, an antioxidant, is explored for its potential to mitigate these risks.
  • There is a need to evaluate the efficacy and safety of vitamin E supplementation during pregnancy.

Purpose of the Study:

  • To assess the impact of vitamin E supplementation, alone or with other supplements, on pregnancy outcomes.
  • To evaluate adverse events, side effects, and healthcare service utilization associated with vitamin E supplementation.
  • To synthesize evidence from randomized controlled trials on vitamin E's role in pregnancy.

Main Methods:

  • Systematic review and meta-analysis of randomized and quasi-randomized controlled trials.
  • Searched the Cochrane Pregnancy and Childbirth Group's Trials Register and reference lists.
  • Included 21 trials with 22,129 women; 17 trials contributed data, mostly combining vitamin E with vitamin C and/or other agents.

Main Results:

  • No clear difference in stillbirth, neonatal death, pre-eclampsia, preterm birth, or intrauterine growth restriction.
  • Vitamin E with other supplements showed a decreased risk of placental abruption (high quality evidence).
  • Increased risk of self-reported abdominal pain and term prelabour rupture of membranes (PROM) was observed.

Conclusions:

  • Routine vitamin E supplementation with other supplements is not supported for preventing major adverse pregnancy outcomes.
  • Further research is needed to clarify vitamin E's role in preventing placental abruption.
  • No convincing evidence of significant benefits or harms from combined vitamin E supplementation in pregnancy was found.