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Sleep Disordered Breathing in Children

Christopher Grime1,2, Hui-leng Tan3,4

  • 1Department of Pediatric Respiratory Medicine, Royal Brompton Hospital, London, SW3 6NP, UK.

Indian Journal of Pediatrics
|September 8, 2015
PubMed

Insights

Sleep-disordered breathing (SDB) encompasses various sleep respiration issues, with obstructive sleep apnea (OSA) being common in children. Understanding OSA

Area of Science:

  • Pediatric Sleep Medicine
  • Respiratory Physiology
  • Genomics and Proteomics

Background:

  • Sleep-disordered breathing (SDB) comprises a range of respiratory abnormalities during sleep.
  • Obstructive sleep apnea (OSA) is the most common SDB in children, impacting neurocognitive, cardiovascular, and metabolic systems.
  • Phenotypic variation in OSA morbidity suggests interplay between genetic and environmental factors.

Purpose of the Study:

  • To review recent advancements in the etiology, pathophysiology, and treatment of pediatric obstructive sleep apnea (OSA).
  • To explore the role of genomics and proteomics in understanding OSA.
  • To emphasize the importance of patient phenotyping for personalized medicine in OSA management.

Main Methods:

  • Literature review focusing on recent developments in pediatric OSA.
  • Exploration of genomic and proteomic research related to OSA.
  • Discussion of personalized medicine approaches for OSA.

Main Results:

  • Recent research is enhancing the understanding of OSA's causes and effects.
  • Genomics and proteomics offer insights into complex OSA pathological pathways.
  • Phenotypic variation necessitates tailored treatment strategies.

Conclusions:

  • Personalized medicine, driven by phenotyping, is crucial for effective OSA management.
  • Further research into genetic and environmental factors will refine treatment.
  • Advances in understanding OSA pathophysiology are paving the way for targeted therapies.

Keywords:
MorbiditiesPathophysiologyPediatric obstructive sleep apnea

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