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Updated: Apr 4, 2026

Protocol for Isolating the Mouse Circle of Willis
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Assessment of the Circle of Willis with Cranial Tomography Angiography

Ayse Karatas1, Gokmen Coban2, Celal Cinar3

  • 1Department of Neurosurgery, Izmir Katip Celebi University Ataturk Education and Research Hospital, Izmir, Turkey.

Medical Science Monitor : International Medical Journal of Experimental and Clinical Research
|September 8, 2015
PubMed

Insights

The study analyzed the circle of Willis in Turkish adults using CTA, finding common variations like posterior communicating artery hypoplasia. Understanding these vascular structures is crucial for cerebrovascular disease management.

Area of Science:

  • Neuroimaging
  • Vascular Anatomy
  • Cerebrovascular Diseases

Background:

  • The circle of Willis is a critical collateral pathway in the brain.
  • Its structural integrity is vital for managing ischemic conditions.

Purpose of the Study:

  • To evaluate the structural characteristics of the circle of Willis in the Turkish adult population.
  • To identify variations in diameters and lengths of its arteries using CTA.

Main Methods:

  • Retrospective analysis of cranial computed tomography angiography (CTA) images.
  • Evaluation of 100 adult patients.

Main Results:

  • Observed 82% adult, 17% fetal, and 1% transitional circle of Willis configurations.
  • A complete polygonal structure was present in 28% of cases.
  • Posterior communicating artery hypoplasia was the most frequent variation.

Conclusions:

  • Arterial patency and size within the circle of Willis are significant for occlusive cerebrovascular diseases and surgery.
  • CTA is a valuable non-invasive tool, but image quality and small vessel identification require careful consideration.
Abstract

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