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Updated: Apr 4, 2026

The Colon-26 Carcinoma Tumor-bearing Mouse as a Model for the Study of Cancer Cachexia
Published on: November 30, 2016
Experimental cancer cachexia: Evolving strategies for getting closer to the human scenario
Fabio Penna1, Sílvia Busquets2, Josep M Argilés2
1Department of Clinical and Biological Sciences, University of Torino, 10125 Torino, Italy.
Abstract:
Cancer cachexia is a frequent syndrome that dramatically affects patient quality of life, anti-cancer treatment effectiveness, and overall survival. To date, no effective treatment is available and most of the studies are performed in experimental models in order to uncover the underlying mechanisms and to design prospective therapeutic strategies. This review summarizes the most relevant information regarding the use of animal models for studying cancer cachexia. Technical limitations and degree of recapitulation of the features of human cachexia are highlighted, in order to help investigators choose the most suitable model according to study-specific endpoints.
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