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Related Concept Videos

Asthma: Pathogenesis and Management01:20

Asthma: Pathogenesis and Management

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Asthma is a chronic pulmonary condition involving inflammation of the airways, hyper-reactivity, and reversible obstruction of the airways. This condition can significantly impact a person's quality of life, making breathing difficult and leading to distressing symptoms.
Asthma is classified as allergic and non-allergic. Allergens such as dust mites, pollen, and pet dander trigger allergic asthma, while factors like cold air, intense emotions, or exercise can induce non-allergic asthma.
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COPD: Management Using Bronchodilators and Corticosteroids01:26

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Chronic obstructive pulmonary isease (COPD) involves a group of progressive lung disorders characterized by persistent airflow limitation and chronic respiratory symptoms. Asthma-COPD Overlap Syndrome (ACOS), encompassing features of both asthma and Chronic obstructive pulmonary disease (COPD), is a group of progressive lung disorders that includes chronic bronchitis, emphysema, and refractory (non-reversible) asthma. ACOS leads to complex clinical presentations that combine the inflammatory...
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Asthma-II: Pathophysiology and Classification01:26

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Asthma is a prevalent chronic respiratory condition marked by inflammation and hyperresponsiveness of the airways. Its pathophysiology involves complex interactions among inflammatory pathways, immune responses, and neural mechanisms.
Additionally, environmental and genetic factors play crucial roles in determining an individual's susceptibility to asthma and the severity of their condition.
Critical processes in asthma pathophysiology include:
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Chronic Obstructive Pulmonary Disease-II: Pathophysiology01:20

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Chronic Obstructive Pulmonary Disease (COPD) pathophysiology is intricate and multifaceted, involving a complex interplay of physiological processes. Understanding these mechanisms is crucial for effectively managing and treating COPD. Here is an in-depth look at the critical elements in the pathophysiology of COPD:
Chronic Inflammation
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Antiasthma Drugs: Mast Cell Stabilizers and Anti-IgE Drugs01:25

Antiasthma Drugs: Mast Cell Stabilizers and Anti-IgE Drugs

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Asthma is a chronic respiratory condition for which new therapeutic avenues, including anti-inflammatory drugs like mast cell stabilizers and anti-IgE treatments, continue to be developed.
Mast cell stabilizers, such as cromolyn (also known as sodium cromoglycate) and nedocromil (Tilade), are effective drugs in asthma management. These stabilizers hinder histamine release by skillfully obstructing the activation of mast cells and other cellular entities. Notably, they navigate this task without...
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Asthma-IV: Diagnostic and Management01:30

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The diagnosis and management of asthma are comprehensive, encompassing clinical assessments, lung function tests, and pharmacological interventions. Here's an overview:
Clinical Assessment for Asthma:
This is the first step in diagnosing and managing asthma. It includes:
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Related Experiment Video

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Bronchial Thermoplasty: A Novel Therapeutic Approach to Severe Asthma
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Recent developments regarding periostin in bronchial asthma.

Kenji Izuhara1, Hisako Matsumoto2, Shoichiro Ohta3

  • 1Division of Medical Biochemistry, Department of Biomolecular Sciences, Saga Medical School, Saga, Japan.

Allergology International : Official Journal of the Japanese Society of Allergology
|September 8, 2015
PubMed
Summary

Serum periostin aids in stratifying asthma patients. It acts as a biomarker for type 2 immune responses and tissue remodeling, enabling personalized asthma treatment strategies.

Keywords:
BiomarkerBronchial asthmaCompanion diagnosticPeriostinStratified medicine

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Area of Science:

  • Immunology
  • Pulmonology
  • Biomarker Discovery

Background:

  • Asthma is a heterogeneous syndrome, necessitating patient stratification for effective treatment.
  • Current therapeutic strategies do not fully leverage asthma's complexity.
  • Identifying biomarkers is crucial for personalized asthma medicine.

Purpose of the Study:

  • To explore the role of periostin as a biomarker in bronchial asthma.
  • To investigate periostin's utility in stratifying asthma patients.
  • To evaluate periostin's potential in developing targeted therapies.

Main Methods:

  • Investigated periostin as a component of subepithelial fibrosis in asthma.
  • Assessed periostin as a surrogate biomarker for type 2 immune responses.
  • Examined serum periostin's ability to predict inhaled corticosteroid response.

Main Results:

  • Periostin is a novel component of subepithelial fibrosis downstream of IL-13 signaling.
  • Serum periostin serves as a surrogate biomarker for type 2 immune responses.
  • Serum periostin predicts resistance to inhaled corticosteroids, reflecting tissue remodeling.

Conclusions:

  • Serum periostin possesses dual biomarker characteristics: surrogate for type 2 immunity and indicator of tissue remodeling.
  • Periostin's properties can facilitate the development of stratified medicine for bronchial asthma.
  • Targeted therapeutic strategies based on periostin levels may improve asthma management.