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Synthesis and biological activity of a cyclic hexapeptide related to peptide T
S Bianchi1, V Scaranari, R Tomatis
1Dipartimento Scienze Farmaceutiche, Università di Ferrara, Italy.
Farmaco (Societa Chimica Italiana : 1989)
|December 1, 1989
Abstract:
The cyclo [Thr-Thr-Thr-Tyr-Asn-Thr] hexapeptide related to peptide T, H-Ala-Ser-Thr-Thr-Thr-Asn-Tyr-Thr-OH, competitor of the Human Immunodeficiency Virus in the binding to human T cells, was synthesized and tested for its ability to stimulate monocyte migration (chemotaxis). The new cyclic derivative showed negligible biological activity.