Related Experiment Video
Updated: Apr 4, 2026
07:14
Enhanced Gene Delivery and Expression using Intraosseous Injection of Chitosan Nanoparticles Encapsulated Adenine Base Editor Plasmids
Published on: May 16, 2025
807
Chondroitin sulfate-based nanocarriers for drug/gene delivery
Lili Zhao1, Mengrui Liu1, Juan Wang2
1Department of Pharmaceutics, College of Pharmacy, Shandong University, Jinan 250012, China.
Carbohydrate Polymers
|September 8, 2015
Summary
Chondroitin sulfate (ChS), a natural polysaccharide, shows great promise for drug and gene delivery systems due to its biocompatibility and low toxicity. This review explores ChS applications in nanocarriers for enhanced therapeutic delivery.
Area of Science:
- Biomaterials Science
- Nanotechnology
- Pharmacology
Background:
- Naturally occurring polysaccharides are increasingly utilized in drug/gene delivery due to favorable properties like biocompatibility and biodegradability.
- Chondroitin sulfate (ChS), a glycosaminoglycan, is composed of repeating disaccharide units and is widely used in nano-sized carriers.
Purpose of the Study:
- To review the shared and unique properties of Chondroitin sulfate (ChS).
- To highlight the latest developments in ChS applications for drug and gene delivery systems.
- To discuss ChS-based nanocarriers in terms of self-assembly, decoration, and other forms.
Main Methods:
- Literature review focusing on Chondroitin sulfate (ChS) properties and applications.
- Analysis of ChS utilization in various nanocarrier systems for drug and gene delivery.
- Discussion of future perspectives for ChS-based nanocarriers.
Main Results:
- Chondroitin sulfate (ChS) exhibits excellent biocompatibility, biodegradability, and low toxicity, making it suitable for drug/gene delivery.
- ChS has been successfully applied in self-assembled nanocarriers, decorated nanocarriers, and other ChS-based nanocarrier systems.
- The review details the versatility of ChS in developing advanced drug/gene delivery platforms.
Conclusions:
- Chondroitin sulfate (ChS) is a versatile biomaterial with significant potential in advanced drug and gene delivery systems.
- Further research into ChS-based nanocarriers is expected to yield innovative therapeutic solutions.
- The unique properties of ChS support its continued development for targeted and efficient delivery applications.
More Related Videos
Related Concept Videos
01:24Site-Targeted Drug Delivery Systems: Polymeric Carriers
113
Polymeric carriers enhance targeted drug delivery by increasing efficacy while minimizing off-target effects. These carriers comprise a biodegradable polymeric backbone integrated with functional elements that enable targeting, improve physicochemical properties, and regulate drug release.Targeting MechanismsThe targeting ability of polymeric carriers is mediated by a homing device, which is a molecular recognition component designed to selectively bind to specific tissues or cells. Monoclonal...
113
01:24Modified-Release Drug Delivery Systems: Site-Targeted
112
Site-targeted drug delivery systems enhance therapeutic efficacy while minimizing systemic toxicity and treatment costs. Unlike conventional methods, these systems ensure precise drug delivery, improving bioavailability and reducing side effects. Targeted drug delivery is classified into three levels. First-order targeting directs drugs to the capillary beds of specific organs or tissues. Second-order targets specific cell types, such as tumor cells, using receptor-mediated interactions.
112
00:59Gene Therapy
28.1K
Gene therapy is a technique where a gene is inserted into a person’s cells to prevent or treat a serious disease. The added gene may be a healthy version of the gene that is mutated in the patient, or it could be a different gene that inactivates or compensates for the patient’s disease-causing gene. For example, in patients with severe combined immunodeficiency (SCID) due to a mutation in the gene for the enzyme adenosine deaminase, a functioning version of the gene can be...
28.1K
01:16Drug Delivery: Overview
1.2K
The selection of a drug's delivery route depends upon its physicochemical properties, including lipid or water solubility and ionization, as well as the therapeutic requirement, such as immediate or sustained effect. These routes can be divided into three primary categories: enteral, parenteral, and topical.
Enteral delivery involves administering drugs directly through swallowing, sublingual placement, or buccal application. Orally administered drugs predominantly navigate the...
Enteral delivery involves administering drugs directly through swallowing, sublingual placement, or buccal application. Orally administered drugs predominantly navigate the...
1.2K
01:19Modified-Release Drug Delivery Systems: Overview
172
Modified-release dosage forms are designed to address the limitations of drugs with short biological half-lives. These forms maintain stable therapeutic drug concentrations over extended periods, reducing the need for frequent dosing. A consistent drug level helps minimize peak-trough fluctuations, which can reduce adverse effects, lower the risk of drug resistance, and improve overall treatment effectiveness.One common type of modified-release form is the extended-release (ER) formulation. ER...
172