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Envelope Glycoprotein Trimers as HIV-1 Vaccine Immunogens

Quentin J Sattentau1

  • 1The Sir William Dunn School of Pathology, The University of Oxford, South Parks Road, Oxford OX13RE, UK. quentin.sattentau@path.ox.ac.uk.

Vaccines
|September 8, 2015
PubMed

The HIV-1 envelope glycoprotein spike is the target of neutralizing antibody attack, and hence represents the only relevant viral antigen for antibody-based vaccine design. Various approaches have been attempted to recapitulate Env in membrane-anchored and soluble forms, and these will be discussed here in the context of recent successes and challenges still to be overcome.

Keywords:
HIV-1envelope glycoproteinsneutralizing antibodiestrimervaccine

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