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Related Concept Videos

Drug Dosing: Geriatric Patients01:15

Drug Dosing: Geriatric Patients

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Elderly individuals encompass a diverse population with varying degrees of age-related physiological changes. Defining the elderly presents challenges, as the geriatric population is often arbitrarily categorized as individuals older than 65. However, many individuals in this group lead active and healthy lives, with an increasing number surpassing 85 years and falling into the older elderly category. Physiological changes associated with aging impact performance capacity and homeostatic...
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Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Distribution01:00

Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Distribution

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Drug distribution in the human body is influenced by several factors, including plasma protein concentration, body composition, blood flow, tissue-protein concentration, and tissue fluid pH. Among these, changes in plasma protein concentration and body composition due to aging significantly affect how drugs are distributed within the body. Specifically, aging is associated with a decrease in albumin levels by about 10% and an increase in α1-acid glycoprotein levels. These alterations are...
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Radiological Investigation III: Pulmonary Angiogram and PET Scan01:13

Radiological Investigation III: Pulmonary Angiogram and PET Scan

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Radiological investigations are paramount in the diagnosis and management of various pulmonary diseases. Two essential investigations are the Pulmonary Angiogram and the Positron Emission Tomography (PET) Scan.
Pulmonary Angiogram
A Pulmonary Angiogram is an invasive procedure involving injecting a contrast medium through a catheter threaded into the pulmonary artery or the right side of the heart to visualize the pulmonary vasculature. Computed Tomography (CT) scans have mainly replaced this...
627
Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Excretion01:18

Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Excretion

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In geriatric patients, renal physiology undergoes significant changes, including diminished renal blood flow and a lower glomerular filtration rate (GFR), leading to alterations in medication clearance. Drugs such as aminoglycoside antibiotics, lithium, and digoxin, which rely on glomerular filtration for removal from the body, particularly impact pharmacokinetics. These drugs tend to have slower clearance rates in older adults, necessitating careful dosage considerations.Evaluation of renal...
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Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Absorption01:22

Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Absorption

813
As individuals age, their body's physiology evolves, affecting drug pharmacokinetics. The most apparent changes occur in the gastrointestinal tract, where an increase in gastric pH, a delay in gastric emptying, and a reduction in gastrointestinal motility are observed. Remarkably, these changes do not substantially modify the absorption of orally administered drugs, particularly those absorbed via passive diffusion.Transdermal drug delivery emerges as a highly viable method for older adults due...
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Radiological Investigation I: X-ray and CT01:30

Radiological Investigation I: X-ray and CT

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Radiological investigations, including X-rays and computed tomography (CT) scans, are critical for diagnosing and evaluating various medical conditions. These imaging techniques provide valuable insights into the body's internal structures, aiding in the detection of abnormalities, assessment of disease progression, and development of treatment strategies. This article delves into two primary radiological investigations, chest X-rays and CT scans, outlining their purpose, procedures, and...
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Updated: Apr 4, 2026

Proton Therapy Delivery and Its Clinical Application in Select Solid Tumor Malignancies
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[Radiation therapy for elderly patients].

C Durdux1, M Gisselbrecht2

  • 1Service de radiothérapie, hôpital européen Georges-Pompidou, 20, rue Leblanc, 75015 Paris, France.

Cancer Radiotherapie : Journal De La Societe Francaise De Radiotherapie Oncologique
|September 8, 2015
PubMed
Summary
This summary is machine-generated.

Radiotherapy is a feasible cancer treatment for older patients. This review focuses on radiation oncology considerations for aging, including technical aspects and new technologies.

Keywords:
AgeCancerElderly patientsRadiotherapyRadiothérapieÂge

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Area of Science:

  • Geriatric oncology
  • Radiation oncology
  • Cancer treatment in the elderly

Context:

  • Cancer predominantly affects older adults, a significant demographic in Western countries.
  • Radiotherapy is a primary and effective cancer treatment modality.
  • Existing research supports the feasibility of radiotherapy for both curative and palliative cancer treatment in elderly patients.

Purpose:

  • To review radiation oncology principles specifically for aging patients.
  • To emphasize logistic and technical considerations in radiation therapy for the elderly.
  • To explore the potential of novel technologies in geriatric radiation oncology.

Summary:

  • This review highlights key aspects of radiation oncology relevant to aging cancer patients.
  • It underscores the importance of geriatric assessment and multidisciplinary care.
  • Discussions include radiation dose, volume, fractionation, and emerging technologies.

Impact:

  • Provides insights for optimizing radiotherapy in the elderly population.
  • Informs clinical practice regarding the specific needs of older cancer patients undergoing radiation.
  • Highlights areas for future research and technological development in geriatric radiation oncology.