[Disordered function of the vascular-thrombocyte link in the hemostatic system during tumor growth]

The influence of tumor (RA-2) growth on the vascular-platelet haemostasis of mongrel rats was studied. The decrease of the antiaggregation properties of vascular wall and high functional activity of platelets with its intravascular aggregation were correlating with processes of tumor growth and dissemination. Anticoagulation activity of vascular wall also decreased. It is suggested that the change detected may play role in the onco-thromboembolic formation, its penetration via vascular wall and metastatic locus development.