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Behavioural changes in dogs treated with corticosteroids.

Lorella Notari1, Oliver Burman1, Daniel Mills1

  • 1Animal Behaviour, Cognition and Welfare Group, School of Life Sciences, Joseph Banks Laboratories, University of Lincoln, Lincoln LN6 7DL, UK.

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Summary
This summary is machine-generated.

Corticosteroid treatment in dogs can lead to significant psycho-behavioral changes, including reduced playfulness and increased fearfulness. These findings highlight the need for veterinary professionals to consider behavioral advice alongside corticosteroid prescriptions.

Keywords:
BehaviourCorticosteroidDogDrugSide-effects

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Area of Science:

  • Veterinary Medicine
  • Animal Behavior
  • Pharmacology

Background:

  • Psychiatric side effects of corticosteroids are well-documented in human medicine.
  • These effects are largely overlooked in veterinary literature despite widespread glucocorticoid use in animals.
  • Corticosteroids are commonly prescribed for various conditions in dogs.

Purpose of the Study:

  • To identify potential psycho-behavioral changes in dogs undergoing corticosteroid therapy.
  • To provide empirical evidence for adverse behavioral effects in veterinary patients.

Main Methods:

  • A survey of 44 dog owners using a validated questionnaire to assess behavioral changes on and off corticosteroid treatment.
  • Behavioral tests on 11 dogs treated with methylprednisolone or prednisolone, assessing reactions to an aversive sound stimulus before and during treatment, compared to 11 controls.

Main Results:

  • Owners reported dogs on corticosteroids were significantly less playful, more nervous, fearful, aggressive (especially around food), prone to barking, startling, and avoidance.
  • Treated dogs investigated food bowls for less time and ate fewer food pieces after hearing a growl compared to controls.

Conclusions:

  • This study provides the first empirical evidence of adverse psycho-behavioral side effects in dogs treated with corticosteroids.
  • Veterinary practitioners should consider behavioral advice when prescribing corticosteroids to mitigate associated risks.