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A Light-Controlled Release System Based on Molecular Recognition of Cyclodextrins.

Isaac Eng Ting Lee1, Akihito Hashidzume1, Akira Harada1

  • 1Department of Macromolecular Science, Graduate School of Science, Osaka University, Toyonaka, Osaka, 560-0043, Japan.

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This study introduces a novel light-controlled release system using cyclodextrins and azobenzene. UV light triggers molecular rearrangements, enhancing the release of encapsulated cargo from polymer aggregates.

Keywords:
azobenzenecyclodextrinhost-guest systemslight-controlled releasemolecular recognition

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Area of Science:

  • Polymer Chemistry
  • Supramolecular Chemistry
  • Materials Science

Background:

  • Molecular recognition is key for controlled release systems.
  • Photoresponsive molecules offer dynamic control over molecular interactions.
  • Cyclodextrins are versatile hosts for molecular encapsulation.

Purpose of the Study:

  • To develop a light-controlled release system using azobenzene and cyclodextrin interactions.
  • To investigate the effect of UV light on the rearrangement of inclusion complexes.
  • To quantify the release of a chemical cargo from polymer aggregates.

Main Methods:

  • Synthesis of poly(sodium acrylate)s with cyclodextrin and azobenzene residues.
  • Formation of polymer aggregates via inclusion complexation.
  • UV irradiation to induce photoisomerization of azobenzene.
  • Dialysis experiments to measure cargo release kinetics.

Main Results:

  • Azobenzene's photoisomerization induced by UV light altered its binding affinity with α- and β-cyclodextrins.
  • Polymer aggregates formed stable inclusion complexes.
  • The ternary mixture (pAαCD/pAβCD/pAAzo) showed significantly higher cargo release compared to binary mixtures.
  • Light-induced rearrangement of inclusion complexes controlled cargo release.

Conclusions:

  • The developed system demonstrates effective light-controlled release of encapsulated cargo.
  • The dynamic rearrangement of supramolecular interactions is a viable strategy for triggered release.
  • This approach holds potential for applications in drug delivery and smart materials.