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A Cell Culture Model for Producing High Titer Hepatitis E Virus Stocks
Published on: June 26, 2020
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Hepatitis E: an emerging global disease - from discovery towards control and cure.
Mehnaaz S Khuroo1, Mohammad S Khuroo2,3
1Department of Pathology, Govt: Medical College Srinagar, Kashmir, India.
Journal of Viral Hepatitis
|September 8, 2015
Summary
Hepatitis E virus (HEV) causes liver disease and infects many animals. Human HEV infections are a growing concern in industrialized nations, often from consuming undercooked meats from reservoirs like swine and deer.
Area of Science:
- Hepatology
- Virology
- Public Health
Background:
- Hepatitis E virus (HEV) is a significant global pathogen causing liver disease.
- HEV exhibits genetic diversity and infects a wide range of animal species, posing zoonotic risks.
- Hepatitis E is increasingly recognized as an autochthonous health issue in industrialized countries.
Purpose of the Study:
- To provide a comprehensive overview of Hepatitis E virus (HEV) epidemiology, transmission, and clinical significance.
- To highlight the zoonotic potential and public health implications of HEV, particularly in industrialized nations.
- To discuss current management strategies, including transfusion transmission risks and therapeutic interventions.
Main Methods:
- Literature review and synthesis of existing data on HEV.
- Analysis of HEV genotypes, animal reservoirs, and transmission routes.
- Review of clinical manifestations, diagnostic considerations, and treatment outcomes.
Main Results:
- HEV is classified into genera Orthohepevirus and Piscihepevirus, with Orthohepevirus A being the primary cause of human infections.
- Domestic swine, wild boar, and deer are key reservoirs for HEV genotypes 3 and 4 in industrialized countries.
- Transmission occurs through contaminated food (undercooked meat/liver), blood transfusions, and potentially chronic infection in immunocompromised individuals.
Conclusions:
- Hepatitis E represents a substantial public health challenge globally, with rising autochthonous cases in developed regions.
- Preventive measures, including food safety and donor screening, are crucial to control HEV transmission.
- Effective treatments like ribavirin and available vaccines offer promising avenues for managing HEV infection.
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