[Establishment and characterization of a human ovarian adenocarcinoma cell line OC-8611]

A cell line designated as OC-8611 was derived from the malignant ascitic fluid of a patient with ovarian serous cystadenocarcinoma. The line showed epithelial morphology under the light or electron microscope. The chromosome number varied widely and showed aneuploidy, the model chromosome number was stable at triploid range. The pathological features of the tumor transplanted in nude mice were similar to those of the original lesions from the patient. Expression of the antigens CA-125, CA-50 and CEA and ability to secrete ovarian hormones were demonstrated in this cell line. This cell line may contribute to the study on ovarian carcinoma.