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Updated: Apr 4, 2026

A Mice Model of Chlorhexidine Gluconate-Induced Peritoneal Damage
Published on: April 28, 2022
Chlorhexidine – history, mechanism and risks
Ayhan Yildirim1, Philipp Metzler, Heinz-Theo Lübbers
1Klinik und Poliklinik für Mund-, Kiefer- und Gesichtschirurgie, Zentrum für Zahnmedizin der Universität Zürich, Zürich, Switzerland.
Abstract:
Chlorhexidine, one of the most frequently prescribed medications, belongs to a group of medicines called antiseptic antibacterial agents. It is indicated as a mouthwash in the treatment of gingivitis, as it cleans the skin after injury and can be used to clean hands before a procedure. Chlorhexidine works by killing or preventing the growth of bacteria on the mucosa or skin. It should not be used in individuals who are known to be hypersensitive to Chlorhexidine gluconate or other ingredients. It may cause some reversible tooth discoloration or an increase in tartar formation.
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