[Haemorheologic changes during tumor development after subcutaneous transplantation of mouse forestomach carcinoma...

After transplantation of FC, there was a latent period of about 3 days until local invasion was first observed. Active local tumor invasion occurred on day 6 (invasion stage). From day 9 when the invasion became extensive lung metastasis developed (early metastatic stage). The lung metastasis was more severe from day 12 (mid metastatic stage) and became widespread from day 15 (late metastatic stage). Lung metastasis was observed in 42.8%, 50% and 73.3% of the mice during early, mid and late metastatic stages, respectively. There was no haemorheologic change observed in the latent period. In the invasion and early metastatic stages, an increase in plasma and whole blood viscosity was evident but the hematocrit and red cell aggregation were normal. As lung metastasis became more and more extensive, all the haemorheologic parameters were markedly decreased.