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Related Experiment Video

Updated: Apr 4, 2026

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Plasmonic vertical dimer arrays as elements for biosensing.

Andreas Horrer1, Katrin Krieg2, Kathrin Freudenberger2

  • 1Institute for Applied Physics and Center LISA+, University of Tübingen, Auf der Morgenstelle 10, 72076, Tübingen, Germany. andreas.horrer@uni-tuebingen.de.

Analytical and Bioanalytical Chemistry
|September 9, 2015
PubMed
Summary
This summary is machine-generated.

Metallic nanoparticles

Keywords:
BiosensingLabel-free immunoassayPlasmonic nanostructuresTestosteroneVertical dimer

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Area of Science:

  • Nanotechnology and Nanoscience
  • Biomedical Engineering
  • Analytical Chemistry

Background:

  • Localized surface plasmon resonances (LSPR) in metallic nanoparticles are highly sensitive to changes in the surrounding refractive index.
  • Molecular binding events near nanoparticles alter the local refractive index, causing a detectable shift in the plasmon resonance.
  • This phenomenon forms the basis for plasmon resonance-based biosensing.

Purpose of the Study:

  • To investigate and compare the sensitivity of antisymmetric resonance in coupled plasmonic vertical dimers versus surface lattice resonance for refractive index sensing.
  • To demonstrate the practical application of this plasmon resonance biosensor in a real-world immunoassay scenario.

Main Methods:

  • Utilizing simulations and experimental sensing to analyze plasmon resonance shifts in coupled plasmonic vertical dimers.
  • Comparing the refractive index sensing capabilities for both bulk and thin molecular layers using antisymmetric resonance and surface lattice resonance.
  • Implementing a testosterone immunoassay on a functionalized sensor surface within a fluidic channel.

Main Results:

  • The antisymmetric resonance in coupled plasmonic vertical dimers exhibits high sensitivity for refractive index sensing.
  • Demonstrated successful detection of antibodies via a testosterone immunoassay, confirming sensor functionality.
  • Quantified the performance of antisymmetric resonance compared to surface lattice resonance for sensing applications.

Conclusions:

  • Coupled plasmonic vertical dimers offer a sensitive platform for refractive index-based biosensing.
  • The developed sensor surface is effective for immunoassay applications, enabling antibody detection.
  • Antisymmetric resonance presents a promising approach for enhanced biosensing performance.