Related Experiment Video
Updated: Apr 4, 2026
11:44
Analysis of Combinatorial miRNA Treatments to Regulate Cell Cycle and Angiogenesis
Published on: March 30, 2019
8.1K
miRNA Influences in NRF2 Pathway Interactions within Cancer Models
Duncan Ayers1, Byron Baron2, Therese Hunter3
1Centre for Molecular Medicine and Biobanking, University of Malta, Msida MSD 2080, Malta ; Faculty of Medical and Human Sciences, The University of Manchester, Manchester M1 7DN, UK.
Journal of Nucleic Acids
|September 9, 2015
Summary
The nuclear factor-erythroid 2 p45-related factor 2 (NRF2) pathway regulates cellular stress responses. Understanding microRNA (miRNA) control over NRF2 signaling is crucial for developing new cancer therapies.
Area of Science:
- Molecular Biology
- Cellular Biology
- Genetics
Background:
- The nuclear factor-erythroid 2 p45-related factor 2 (NRF2) transcription factor is a master regulator of cellular adaptation to stress.
- NRF2 pathway dysregulation is linked to inflammatory diseases and cancer.
- NRF2 interacts with multiple signaling pathways, and its regulation by microRNAs (miRNAs) is an emerging area of research.
Purpose of the Study:
- To investigate the epigenetic gene regulatory control of the NRF2 signaling pathway by miRNAs.
- To explore the influence of miRNA on NRF2 pathway crosstalk, especially in cancer models.
- To identify potential miRNA targets for translational cancer therapies.
Main Methods:
- Literature review of NRF2 signaling and miRNA interactions.
- Analysis of epigenetic mechanisms regulating NRF2.
- Examination of miRNA-mediated NRF2 modulation in cancer contexts.
Main Results:
- NRF2 is a key player in cellular stress response and disease.
- miRNAs can epigenetically modulate NRF2 pathway components.
- Specific miRNAs show potential for targeting NRF2 in cancer.
Conclusions:
- Epigenetic regulation of NRF2 by miRNAs is clinically significant.
- Identifying miRNA regulators of NRF2 offers therapeutic opportunities in oncology.
- Further research into miRNA-NRF2 interactions can advance translational medicine.
Related Concept Videos
02:26NF-κB-dependent Signaling Pathway
10.4K
The transcription factor NF-κB was discovered in 1986 in the lab of Nobel laureate Professor David Baltimore, for its interaction with the immunoglobulin light chain enhancer in B-cells. After more than three decades of study, it is now evident that NF-κB regulates the expression of over 100 genes. Most of these genes play an essential role in the innate and adaptive immune responses as well as the inflammatory responses of animals.
NF-κB-dependent Signaling Mechanism
The...
NF-κB-dependent Signaling Mechanism
The...
10.4K
01:22MicroRNAs
4.3K
MicroRNA (miRNA) are short, regulatory RNA transcribed from introns (non-coding regions of a gene) or intergenic regions (stretches of DNA present between genes). Several processing steps are required to form biologically active, mature miRNA. The initial transcript, called primary miRNA (pri-mRNA), base-pairs with itself, forming a stem-loop structure. Within the nucleus, an endonuclease enzyme, called Drosha, shortens the stem-loop structure into hairpin-shaped pre-miRNA. After the pre-miRNA...
4.3K
01:22MicroRNAs
24.7K
MicroRNA (miRNA) are short, regulatory RNA transcribed from introns—non-coding regions of a gene—or intergenic regions—stretches of DNA present between genes. Several processing steps are required to form biologically active, mature miRNA. The initial transcript, called primary miRNA (pri-mRNA), base-pairs with itself forming a stem-loop structure. Within the nucleus, an endonuclease enzyme, called Drosha, shortens the stem-loop structure into hairpin-shaped pre-miRNA. After...
24.7K
01:19Interactions Between Signaling Pathways
7.9K
Signaling cascades usually lack linearity. Multiple pathways interact and regulate one another, allowing cells to integrate and respond to diverse environmental stimuli.
Convergence and divergence, and cross-talk between signaling pathways
Two distinct signaling pathways can converge on a single functional unit, which may either be a single protein or a complex of proteins. The response is either functionally distinct or synergistic between the two pathways but different from the response...
Convergence and divergence, and cross-talk between signaling pathways
Two distinct signaling pathways can converge on a single functional unit, which may either be a single protein or a complex of proteins. The response is either functionally distinct or synergistic between the two pathways but different from the response...
7.9K
03:03mTOR Signaling and Cancer Progression
5.1K
The mammalian target of rapamycin or mTOR protein was discovered in 1994 due to its direct interaction with rapamycin. The protein gets its name from a yeast homolog called TOR. The mTOR protein complex in mammalian cells plays a major role in balancing anabolic processes such as the synthesis of proteins, lipids, and nucleotides and catabolic processes, such as autophagy in response to environmental cues, such as availability of nutrients and growth factors.
The mTOR pathway or the...
The mTOR pathway or the...
5.1K
03:03mTOR Signaling and Cancer Progression
1.7K
1.7K