[Mutations in epigenetic and metabolic regulators in peripheral T-cell lymphoma]

Recent advances in sequencing technologies led us to the discovery of mutations in epigenetic and metabolic regulators in peripheral T-cell lymphoma (PTCL). Frequencies of these mutations were found to be especially high in PTCL with features of follicular helper T cells (TFH). These mutations are also identifiable in myeloid malignancies as well as PTCL, suggesting that abnormalities in epigenetic and metabolic pathways are likely to be the fundamental mechanisms underlying various types of hematologic malignancies. The downstream pathways of these mutations have been extensively analyzed in myeloid malignancies, but have yet to be elucidated in PTCL. We clarified a downstream pathway of TET2 mutations in PTCL by analyzing TET2 knockdown mice.